Coffee consumption has been investigated as a protective factor against cancer. Coffee is a complex beverage that contains more than 1000 described phytochemicals, which are responsible for its pleasant taste, aroma, and health-promoting properties. Many of these compounds have a potential therapeutic effect due to their antioxidant, anti-inflammatory, antifibrotic, and anticancer properties. The roasting process affects the phytochemical content, and undesirable compounds may be formed. In recent years, there have been contradictory publications regarding the effect of coffee drinking and cancer. Therefore, this study is aimed at evaluating the association of coffee consumption with the development of cancer. In PubMed, until July 2021, the terms “Coffee and cancer” resulted in about 2150 publications, and almost 50% of them have been published in the last 10 years. In general, studies published in recent years have shown negative associations between coffee consumption and the risk or development of different types of cancer, including breast, prostate, oral, oral and pharyngeal, melanoma, skin and skin nonmelanoma, kidney, gastric, colorectal, endometrial, liver, leukemic and hepatocellular carcinoma, brain, and thyroid cancer, among others. In contrast, only a few publications demonstrated a double association between coffee consumption and bladder, pancreatic, and lung cancer. In this review, we summarize the in vitro and in vivo studies that accumulate epidemiological evidence showing a consistent inverse association between coffee consumption and cancer.

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咖啡作为抗癌饮料的十年研究

咖啡消费已被研究为预防癌症的保护因素。咖啡是一种复杂的饮料，含有超过 1000 种已描述的植物化学物质，这些植物化学物质具有令人愉悦的味道、香气和促进健康的特性。由于它们的抗氧化、抗炎、抗纤维化和抗癌特性，许多这些化合物具有潜在的治疗作用。烘烤过程会影响植物化学成分，并且可能会形成不需要的化合物。近年来，关于喝咖啡和癌症的影响的出版物相互矛盾。因此，本研究旨在评估咖啡消费与癌症发展的关系。在 PubMed 中，直到 2021 年 7 月，“咖啡与癌症”一词导致了大约 2150 篇出版物，其中近 50% 是在过去 10 年发表的。总的来说，近年来发表的研究表明，咖啡消费与不同类型癌症的风险或发展之间存在负相关关系，包括乳腺癌、前列腺癌、口腔癌、口腔癌和咽癌、黑色素瘤、皮肤和皮肤非黑色素瘤、肾癌、胃癌、结肠直肠癌、子宫内膜癌、肝癌、白血病和肝细胞癌、脑癌和甲状腺癌等。相比之下，只有少数出版物表明咖啡消费与膀胱癌、胰腺癌和肺癌之间存在双重关联。在这篇评论中，我们总结了 口腔和咽癌、黑色素瘤、皮肤和皮肤非黑色素瘤、肾癌、胃癌、结肠直肠癌、子宫内膜癌、肝癌、白血病和肝细胞癌、脑癌和甲状腺癌等。相比之下，只有少数出版物表明咖啡消费与膀胱癌、胰腺癌和肺癌之间存在双重关联。在这篇评论中，我们总结了 口腔和咽癌、黑色素瘤、皮肤和皮肤非黑色素瘤、肾癌、胃癌、结肠直肠癌、子宫内膜癌、肝癌、白血病和肝细胞癌、脑癌和甲状腺癌等。相比之下，只有少数出版物表明咖啡消费与膀胱癌、胰腺癌和肺癌之间存在双重关联。在这篇评论中，我们总结了积累流行病学证据的体外和体内研究表明，咖啡消费与癌症之间存在一致的负相关关系。