Strategies for the use of COVID-19 vaccines in children and young adults (in particular university students) are hotly debated and important to optimize. As of late August 2021, recommendations on the use of these vaccines in children vary across different countries. Recommendations are more uniform for vaccines in young adults, but vaccination uptake in this age group shows a large range across countries. Mandates for vaccination of university students are a particularly debated topic with many campuses endorsing mandates in the USA in contrast to European countries, at least as of August 2021. The commentary discusses the potential indirect impact of vaccination of youth on the COVID-19 burden of disease for other age groups and societal functioning at large, estimates of direct impact on reducing fatalities and nonlethal COVID-19-related events in youth, estimates of potential lethal and nonlethal adverse events from vaccines and differential considerations that may exist in the USA, European countries and nonhigh-income countries. Decision-making for deploying COVID-19 vaccines in young people is subject to residual uncertainty on the future course of the pandemic and potential evolution towards endemicity. Rational recommendations would also benefit from better understanding of the clinical and sociodemographic features of COVID-19 risk in young populations and from dissecting the role of re-infections and durability of natural vs. vaccine-induced immunity.

中文翻译：

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儿童和大学生的 COVID-19 疫苗接种

在儿童和年轻人（尤其是大学生）中使用 COVID-19 疫苗的策略受到热烈讨论，并且需要优化。截至 2021 年 8 月下旬，关于在儿童中使用这些疫苗的建议因国家/地区而异。对年轻人接种疫苗的建议更为统一，但该年龄段的疫苗接种率在各个国家/地区存在很大差异。至少在 2021 年 8 月，与欧洲国家相比，大学生接种疫苗的要求是一个特别有争议的话题，与欧洲国家相比，美国的许多校园都支持这项要求。评论讨论了青年接种疫苗对 COVID-19 负担的潜在间接影响。其他年龄组和整个社会功能的疾病，对减少青年死亡率和非致命性 COVID-19 相关事件的直接影响的估计、疫苗导致的潜在致命和非致命性不良事件的估计以及美国、欧洲国家和非高收入国家可能存在的不同考虑因素。在年轻人中部署 COVID-19 疫苗的决策取决于大流行的未来进程和向地方流行的潜在演变的剩余不确定性。更好地了解年轻人群体中 COVID-19 风险的临床和社会人口学特征，以及剖析再感染的作用和自然免疫与疫苗诱导免疫的持久性，也将有助于提出合理的建议。欧洲国家和非高收入国家。在年轻人中部署 COVID-19 疫苗的决策取决于大流行的未来进程和向地方流行的潜在演变的剩余不确定性。更好地了解年轻人群体中 COVID-19 风险的临床和社会人口学特征，以及剖析再感染的作用和自然免疫与疫苗诱导免疫的持久性，也将有助于提出合理的建议。欧洲国家和非高收入国家。在年轻人中部署 COVID-19 疫苗的决策取决于大流行的未来进程和向地方流行的潜在演变的剩余不确定性。更好地了解年轻人群体中 COVID-19 风险的临床和社会人口学特征，以及剖析再感染的作用和自然免疫与疫苗诱导免疫的持久性，也将有助于提出合理的建议。