The development of pancreatic ductal adenocarcinoma (PDAC) is closely tied with the immune system. C-C motif chemokine ligands (CCL) were proved to lead to immune recruitment and training. Thus, we reckoned CCL2 to be the kernel of immune suppression in PDAC tissues.

中文翻译：

---

胰腺导管腺癌产生的 CCL2 对单核细胞髓源性抑制细胞的积累和激活至关重要

胰腺导管腺癌 (PDAC) 的发展与免疫系统密切相关。CC 基序趋化因子配体 (CCL) 被证明可导致免疫募集和训练。因此，我们认为 CCL2 是 PDAC 组织中免疫抑制的核心。