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Construction of Hohenbuehelia serotina polysaccharides-mucin nanoparticles and their sustain-release characteristics under simulated gastrointestinal digestion in vitro
International Journal of Biological Macromolecules ( IF 8.2 ) Pub Date : 2021-09-16 , DOI: 10.1016/j.ijbiomac.2021.09.068
Siying An 1 , Lu Wang 1 , Peng Zhou 2 , Zhen Luo 1 , Ru Feng 1 , Xiaoyu Li 3
Affiliation  

In this study, Hohenbuehelia serotina polysaccharides-mucin nanoparticles (HSP-MC NPs) were fabricated based on hydrogen bonding and hydrophobicity effects for improving the bioavailability of HSP. The structural characteristics and morphology of HSP-MC NPs prepared by different conditions were respectively identified and observed. The results showed that HSP-MC NPs (HSP/MC, 1/1, w/w) presented the optimal physicochemical characteristics, with the encapsulation efficiency of 88.09 ± 0.01%, average particle size of 509.4 ± 9.76 nm and zeta potential of −20.6 ± 0.7 mV. Furthermore, HSP-MC NPs (HSP/MC, 1/1, w/w), belonged to non-crystalline substances, exhibited the excellent physicochemical stabilities against temperature, pH and ionic strength, and had the uniform spherical morphological characteristics. In addition, under simulated gastrointestinal digestion in vitro, HSP-MC NPs (HSP/MC, 1/1, w/w) showed the good sustained release performances, that might effectively improve the absorption rate of HSP. The present research is meaningful for designing the polysaccharides-loaded nano-delivery system based on natural non-toxic carrier that can be used in function food field.



中文翻译:

海菖蒲多糖-黏蛋白纳米粒的构建及其体外模拟胃肠消化的缓释特性

在本研究中,Hohenbuehelia serotina基于氢键和疏水作用制备多糖-粘蛋白纳米颗粒(HSP-MC NPs),以提高 HSP 的生物利用度。分别对不同条件下制备的HSP-MC NPs的结构特征和形貌进行了鉴定和观察。结果表明,HSP-MC NPs (HSP/MC, 1/1, w/w) 具有最佳的理化特性,包封率为 88.09 ± 0.01%,平均粒径为 509.4 ± 9.76 nm,zeta 电位为 - 20.6 ± 0.7 毫伏。此外,HSP-MC NPs (HSP/MC, 1/1, w/w)属于非结晶物质,对温度、pH值和离子强度表现出优异的物理化学稳定性,并具有均匀的球形形态特征。此外,在体外模拟胃肠道消化下,HSP-MC NPs (HSP/MC, 1/1, w/w) 表现出良好的缓释性能,可有效提高 HSP 的吸收率。本研究对于设计基于天然无毒载体的多糖纳米递送系统可用于功能食品领域具有重要意义。

更新日期:2021-09-17
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