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Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata
Natural Products and Bioprospecting Pub Date : 2021-09-16 , DOI: 10.1007/s13659-021-00318-9
Chang-An Geng 1 , Zhen-Tao Deng 1 , Qian Huang 1 , Chun-Lei Xiang 2 , Ji-Jun Chen 1, 3
Affiliation  

Ten 3,5-dimethylcoumarins (16 and 811) involving six new ones (16), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and C. pseudobracteata. The structures of the new compounds were determined by extensive HRESIMS, 1D and 2D NMR spectroscopic analyses. According to the substitution at C-5, these coumarins were classified into 5-methyl, 5-hydroxymethyl, 5-formyl, and 5-nor types. All the isolates were assayed for their inhibition on α-glucosidase, protein tyrosine phosphatase 1B, and T-cell protein tyrosine phosphatase in vitro.

Graphic Abstract



中文翻译:

Chelonopsis praecox、Chelonopsis odontochila 和 Chelonopsis pseudobracteata 中的六种新的 3,5-二甲基香豆素

十3,5- dimethylcoumarins(1 - 68 - 11)涉及六个新的(1 - 6),连同已知的3-甲基香豆素(7),从三个的地上部分分离铃子香属植物蜡梅C. odontochilaC. pseudobracteata。新化合物的结构通过广泛的 HRESIMS、1D 和 2D NMR 光谱分析确定。根据 C-5 处的取代基,这些香豆素分为 5-甲基、5-羟甲基、5-甲酰基和 5-类型。体外测定了所有分离物对α-葡萄糖苷酶、蛋白酪氨酸磷酸酶 1B 和 T 细胞蛋白酪氨酸磷酸酶的抑制作用。

图形摘要

更新日期:2021-09-16
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