Well-dispersed chiral Ag₂S quantum dots (Ag₂S QDs) were facilely synthesized by using N-acetyl-L-cysteine (NALC) as the chiral ligand and loaded onto nanosheets of two-dimensional (2D) few-layer carbon nitride (C₃N₄). The resultant nanocomposite (Ag₂S QDs/few-layer C₃N₄) shows enhanced electrochemiluminescence (ECL) while maintaining the chirality of Ag₂S QDs, which can be used for the chiral discrimination of the enantiomers of tyrosine (Tyr). Due to the higher affinity of chiral Ag₂S QDs toward L-Tyr than toward its enantiomer, the ECL intensity of Ag₂S QDs/few-layer C₃N₄ is significantly decreased after its incubation with L-Tyr, and thus the Tyr enantiomers can be discriminated. The developed ECL chiral sensor exhibits high stability and reproducibility. The universality of the ECL chiral sensor for the discrimination of other chiral amino acids is also studied, and the results indicate that it can work only in the case of chiral aromatic amino acids.

中文翻译：

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手性 Ag2S 量子点/几层氮化碳纳米片的电化学发光手性鉴别

通过使用N-乙酰基-L-半胱氨酸 (NALC) 作为手性配体，轻松合成分散良好的手性 Ag ₂ S 量子点 (Ag ₂ S QD)并加载到二维 (2D) 少层氮化碳纳米片上(C ₃ N ₄ )。所得纳米复合材料（Ag ₂ S QDs/几层C ₃ N ₄）显示出增强的电化学发光（ECL），同时保持了Ag ₂ S QDs的手性，可用于酪氨酸（Tyr）对映体的手性区分。由于手性 Ag ₂ S QD 对L 的亲和力更高-Tyr 与其对映体相比，Ag ₂ S QDs/少层 C ₃ N ₄的 ECL 强度在与L -Tyr孵育后显着降低，因此可以区分 Tyr 对映体。开发的 ECL 手性传感器具有高稳定性和可重复性。还研究了ECL手性传感器在区分其他手性氨基酸方面的通用性，结果表明它只能在手性芳香族氨基酸的情况下起作用。