In our continuous search for antibacterial agents against Pseudomonas syringae pv. actinidiae (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A–D (1–4), were characterized from the fungus Zopfiella sp. The structures were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds 1 and 3 exhibited antibacterial activity against Psa with MIC values of 25 and 50 μg/mL, respectively. This is the first report of anti-Psa activity of cytochalasin derivatives.

中文翻译：

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Zopfiellasins A-D，来自猕猴桃相关真菌 Zopfiella sp. 的两对差向异构细胞松弛素。及其抗菌评估

在我们不断寻找针对丁香假单胞菌pv 的抗菌剂的过程中。梨（PSA）从猕猴桃相关真菌中，两对差向异构体细胞松弛素的，zopfiellasins A-d（1 - 4），是从真菌特征Zopfiella藻。结构是在光谱数据分析的基础上建立的，而绝对构型是通过单晶 X 射线衍射确定的。化合物1和3对 Psa 表现出抗菌活性，MIC 值分别为 25 和 50 μg/mL。这是关于细胞松弛素衍生物的抗 Psa 活性的第一份报告。