Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous Ti6Al4V (pTi) bone plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on the pTi bone plates. The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone, and no stress shielding occurred. In vitro experiments showed that compared with pTi plates, Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold. To better evaluate the function of the Ta-coated bone plate, animal experiments were conducted using a coat tibia fracture model. Our results showed that the Ta-coated bone plate could effectively fix the fracture. Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation. Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone. Therefore, this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.

金属钢板以其高强度的优势一直是临床内骨折固定的金标准。然而，高弹性模量会导致应力屏蔽并导致骨脆化。本研究使用电子束熔化法制备个性化多孔 Ti6Al4V (pTi) 骨板。然后，化学气相沉积 (CVD) 技术在 pTi 骨板上涂覆金属钽 (Ta)。制备的多孔Ta包覆骨板具有与皮质骨相似的弹性模量，不发生应力屏蔽。体外实验表明，与pTi板相比，Ta涂层显着增强了细胞在支架表面的附着和增殖。为了更好地评估 Ta 涂层骨板的功能，使用涂层胫骨骨折模型进行了动物实验。我们的结果表明，Ta 涂层接骨板可以有效地固定骨折。影像学和组织学分析均表明，Ta 涂层骨板对愈伤组织形成具有显着的间接结合。组织学结果显示新骨在界面处生长，并与宿主骨形成良好的骨结合。因此，本研究为骨科应用提供了一种具有改善的骨整合和成骨功能的生物功能性 Ta 涂层骨板的替代方案。