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BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants
bioRxiv - Microbiology Pub Date : 2021-09-14 , DOI: 10.1101/2021.09.13.460163
Jianying Liu , Yang Liu , Hongjie Xia , Jing Zou , Scott Weaver , Kena A. Swanson , Hui Cai , Mark Cutler , David Cooper , Alexander Muik , Kathrin U. Jansen , Ugur Sahin , Xuping Xie , Philip R. Dormitzer , Pei-Yong Shi

BNT162b2-elicited human sera are known to neutralize the currently dominant Delta SARS-CoV-2 variant. Here, we report the ability of 20 human sera, drawn 2 or 4 weeks after two doses of BNT162b2, to neutralize USA-WA1/2020 SARS-CoV-2 bearing variant spikes from Delta plus (Delta-AY.1, Delta-AY.2), Delta-Δ144 (Delta with the Y144 deletion of the Alpha variant), Lambda, and B. 1.1.519 lineage viruses. Geometric mean plaque reduction neutralization titers against Delta-AY.1, Delta-AY.2, and Delta-Δ144 viruses are slightly lower than against USA-WA1/2020, but all sera neutralize the variant viruses to titers of ≥80.

中文翻译:

BNT162b2 引发的 Delta Plus、Lambda 和其他变体的中和

已知 BNT162b2 引发的人类血清可以中和目前占主导地位的 Delta SARS-CoV-2 变体。在这里,我们报告了在两剂 BNT162b2 后 2 或 4 周抽取的 20 份人类血清中和来自 Delta plus(Delta-AY.1、Delta-AY .2)、Delta-Δ144(带有 Alpha 变体 Y144 缺失的 Delta)、Lambda 和 B. 1.1.519 谱系病毒。针对 Delta-AY.1、Delta-AY.2 和 Delta-Δ144 病毒的几何平均噬斑减少中和滴度略低于针对 USA-WA1/2020,但所有血清都将变异病毒中和至≥80 的滴度。
更新日期:2021-09-16
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