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A New Anthraquinone-Aurone Adduct with Hepatoprotective Activity from the Fruits of Cucumis bisexualis
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-09-15 , DOI: 10.1007/s10600-021-03490-z
Qinge Ma 1 , Rongrui Wei 1
Affiliation  

A previously undescribed anthraquinone-aurone adduct 1, named 8-(4′-hydroxy-3′,5′-dimethoxyphenyl)-12-hydroxy-7-(6′′,7′′-dimethylfuran-2′′-one)-9,16-anthraquinone-furochromene-3,2′′-dione, was isolated from the fruits of Cucumis bisexualis. Its structure was determined by comprehensive spectroscopic data and references. Compound 1 was evaluated for its inhibitory effect against the increase in AST and ALT levels in H2O2-induced HepG2 cells in the range of their maximum nontoxic concentration. Compound 1 exhibited moderate hepatoprotective activities in vitro.



中文翻译:

双性黄瓜果实中一种新的具有保肝活性的蒽醌-金酮加合物

以前未描述的蒽醌-金酮加合物1,命名为 8-(4'-羟基-3',5'-二甲氧基苯基)-12-羟基-7-(6'',7''-二甲基呋喃-2''-one) -9,16-anthraquinone-furochromene-3,2''-dione,是从 Cucumis bisexualis 的果实中分离出来的。其结构由综合光谱数据和参考资料确定。评估了化合物1在其最大无毒浓度范围内对 H2O2 诱导的 HepG2 细胞中 AST 和 ALT 水平增加的抑制作用。化合物1在体外表现出中等的保肝活性。

更新日期:2021-09-16
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