A new N-cis-coumaroyltyramine derivative, fissistyramine (1), along with four known coumaroyltyramine derivatives (2–5), was isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. The structure of the new compound 1 was determined by 1D and 2D NMR as well as by HR-ESI-MS. The inhibitory effect of all the compounds on the proliferation of primary synovial cells was evaluated. Compounds 1, 2, and 5 exhibited inhibitory activity on synoviocytes, with IC₅₀ values of 12.1, 13.8, and 15.6 μM.

中文翻译：

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一种新的来自 Fissistigma oldhamii 的 N-顺式-香豆酰基酪胺衍生物

从 Fissistigma oldhamii (Hemsl.) Merr 的茎中分离出一种新的 N-顺式-香豆酰基酪胺衍生物，fissistyramine ( 1 )，以及四种已知的香豆酰基酪胺衍生物 ( 2-5 )。新化合物1的结构由 1D 和 2D NMR 以及 HR-ESI-MS 确定。评价了所有化合物对初级滑膜细胞增殖的抑制作用。化合物1，2，和5显示出在滑膜细胞的抑制活性，带IC ₅₀ 12.1，13.8，和15.6μM的值。