ABSTRACT

Purpose

To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO).

Methods

A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and neutrophil/ lymphocyte ratio (NLR) were calculated.

Results

RDW, PLR, SII and NLR values were significantly higher in CRAO group than control group [15.2 ± 1.47% vs 13.96 ± 1.13% (p < .001), 127.94 ± 48.21 vs 101.16 ± 24.84 (p = .008), 667.11 ± 357.84 vs 493.44 ± 207.07 (p = .008), 2.70 ± 1.27 vs 2.13 ± 0.83 (p = .018), respectively]. In multivariate analysis only RDW was independent predictor for CRAO (OR 2.317, p < .001). On ROC analysis, area under curve of RDW, PLR, SII, and NLR for CRAO were 0.761, 0.685, 0.622 and 0.618, respectively.

Conclusion

RDW seems superior to other inflammatory indices to predict CRAO.

中文翻译：

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视网膜中央动脉闭塞患者红细胞分布宽度、血小板/淋巴细胞比率、全身免疫炎症指数和中性粒细胞/淋巴细胞比率值的评估

摘要

目的

评估视网膜中央动脉闭塞 (CRAO) 中全血细胞计数 (CBC) 衍生的炎症指标。

方法

总共包括 42 名 CRAO 患者（CRAO 组）和 42 名年龄和性别匹配的无 CRAO 受试者（对照组）。测定了包括红细胞分布宽度 (RDW) 水平在内的 CBC 参数。计算血小板/淋巴细胞比率（PLR）、全身免疫炎症指数（SII）和中性粒细胞/淋巴细胞比率（NLR）。

结果

CRAO 组的 RDW、PLR、SII 和 NLR 值显着高于对照组 [15.2 ± 1.47% vs 13.96 ± 1.13% (p < .001)、127.94 ± 48.21 vs 101.16 ± 24.84 (p = .008)、667.11 ± 357.84 对 493.44 ± 207.07 (p = .008)，2.70 ± 1.27 对 2.13 ± 0.83 (p = .018)。在多变量分析中，只有 RDW 是 CRAO 的独立预测因子 (OR 2.317, p < .001)。在 ROC 分析中，CRAO 的 RDW、PLR、SII 和 NLR 曲线下面积分别为 0.761、0.685、0.622 和 0.618。

结论

RDW 似乎优于其他炎症指标来预测 CRAO。