Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes to the underlying basement membrane. Integrin α6β4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, α6β4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival. In this Review, we detail the role of α6β4 in HD assembly and beyond, and we discuss the molecular mechanisms that regulate its function.

中文翻译：

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整合素α6β4对半桥粒动力学和细胞信号传导的调节。

半桥粒 (HD) 是一种特殊的多蛋白复合物，可将上皮细胞的角蛋白细胞骨架与细胞外基质 (ECM) 连接起来。在皮肤中，这些复合物使基底角质形成细胞稳定地粘附在下面的基底膜上。整合素 α6β4 是层粘连蛋白的受体，通过启动 HD 的组装在介导细胞粘附中发挥重要作用。此外，α6β4 与调节多种细胞过程（包括增殖和存活）的信号转导事件有关。在这篇综述中，我们详细介绍了 α6β4 在 HD 组装及其他方面的作用，并讨论了调节其功能的分子机制。