PURPOSE Common residual symptoms among survivors of colorectal cancer (CRC) are sleep difficulties and gastrointestinal symptoms. Among patients with various gastrointestinal (inflammatory) diseases, sleep quality has been related to gastrointestinal symptoms. For CRC survivors, this relation is unclear; therefore, we examined the association between sleep quality and quantity with gastrointestinal symptoms among CRC survivors. METHODS CRC survivors registered in the Netherlands Cancer Registry-Southern Region diagnosed between 2000 and 2009 received a survey on sleep quality and quantity (Pittsburgh Sleep Quality Index) and gastrointestinal symptoms (European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire-Colorectal 38, EORTC QLQ-CR38) in 2014 (≥ 4 years after diagnosis). Secondary cross-sectional data analyses related sleep quality and quantity separately with gastrointestinal symptoms by means of logistic regression analyses. RESULTS In total, 1233 CRC survivors were included, of which 15% reported poor sleep quality. The least often reported gastrointestinal symptom was pain in the buttocks (15.1%) and most often reported was bloating (29.2%). CRC survivors with poor sleep quality were more likely to report gastrointestinal symptoms (p's < 0.01). Survivors who slept < 6 h were more likely to report symptoms of bloating or flatulence, whereas survivors who slept 6-7 h reported more problems with indigestion. CONCLUSIONS Worse sleep quality and short sleep duration were associated with higher occurrence of gastrointestinal symptoms. IMPLICATIONS FOR CANCER SURVIVORS Understanding the interplay between sleep quality and gastrointestinal symptoms and underlying mechanisms adds to better aftercare and perhaps reduction of residual gastrointestinal symptoms in CRC survivors by improving sleep quality.

中文翻译：

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结直肠癌幸存者的睡眠质量、睡眠量和胃肠道问题之间的关系：来自 PROFILES 登记的结果。

目的 结直肠癌 (CRC) 幸存者的常见残留症状是睡眠困难和胃肠道症状。在患有各种胃肠道（炎症）疾病的患者中，睡眠质量与胃肠道症状有关。对于 CRC 幸存者，这种关系尚不清楚；因此，我们检查了 CRC 幸存者的睡眠质量和数量与胃肠道症状之间的关系。方法 2000 年至 2009 年间在荷兰癌症登记处登记的 CRC 幸存者 - 南部地区被诊断出接受了关于睡眠质量和数量（匹兹堡睡眠质量指数）和胃肠道症状（欧洲癌症研究和治疗组织，生活质量问卷 - 结直肠癌）的调查。 38，EORTC QLQ-CR38）在 2014 年（诊断后≥ 4 年）。次要横断面数据通过逻辑回归分析分别分析相关睡眠质量和数量与胃肠道症状。结果 共纳入 1233 名 CRC 幸存者，其中 15% 报告睡眠质量差。最不常报告的胃肠道症状是臀部疼痛（15.1%），最常报告的是腹胀（29.2%）。睡眠质量差的 CRC 幸存者更有可能出现胃肠道症状（p < 0.01）。睡眠 < 6 小时的幸存者更有可能报告腹胀或肠胃胀气的症状，而睡眠 6-7 小时的幸存者报告的消化不良问题更多。结论 较差的睡眠质量和较短的睡眠时间与较高的胃肠道症状发生率相关。