当前位置: X-MOL 学术Int. J. Med. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Impact of Motor Disability and the Level of Fatigue on Adherence to Therapeutic Recommendations in Patients with Multiple Sclerosis Treated with Immunomodulation.
International Journal of Medical Sciences ( IF 3.6 ) Pub Date : 2021-08-27 , DOI: 10.7150/ijms.61964
Robert Ślusarz 1, 2 , Joanna Olkiewicz 2, 3 , Robert Bonek 3 , Karolina Filipska 1, 2 , Monika Biercewicz 4 , Adam Wiśniewski 5
Affiliation  

Aim: The aim of the study was to clarify whether the motor disability and the fatigue-related syndrome affect the level of compliance with therapeutic recommendations. Methods: Prospective studies were conducted among 165 patients treated under the drug program - Treatment of Multiple Sclerosis (MS) at the Department of Neurology and Clinical Neuroimmunology of the Regional Specialist Hospital in Grudziadz (Poland). The research was carried out by the method of diagnostic survey, questionnaire technique with the use of standardized research tools. The Adherence in Chronic Diseases Scale (ACDS) was used to assess the level of compliance with therapeutic recommendations. The Expanded Disability Status Scale (EDSS) was used to assess the degree of disability, and the Modified Fatigue Impact Scale (MFIS) was used to assess the degree of disability. The Chi-square test, Shapiro-Wilk test and Kruskal-Wallis were used. Results: The statistical analysis showed that there is a relationship (p=0.0055) between the patient's motor disability assessed in the EDSS scale and the level of compliance with therapeutic recommendations assessed in the ACDS scale. The higher the patient's disability level (EDSS 4.5-6.5), the lower the treatment adherence rate. The conducted research shows that the average score in the MFIS scale for individual levels of compliance with therapeutic recommendations expressed in the ACDS scale is, respectively: for the low level - 38.3 MFIS points, for the medium level - 34.4 MFIS points and for the high level- 33.2 MFIS points. The obtained results were not statistically significant (p=0.6098). Conclusion: It was found that the level of adherence to therapeutic recommendations in patients with relapsing-remitting multiple sclerosis treated with immunomodulation in the study group remained high. There is a relationship between the patient's disability and the level of adherence to therapeutic recommendations.

中文翻译:

运动障碍和疲劳程度对接受免疫调节治疗的多发性硬化症患者遵守治疗建议的影响。

目的:该研究的目的是澄清运动障碍和疲劳相关综合征是否影响对治疗建议的依从程度。方法:对格鲁齐亚兹(波兰)地区专科医院神经病学和临床神经免疫学部门接受药物治疗多发性硬化症 (MS) 治疗的 165 名患者进行前瞻性研究。本研究采用诊断调查、问卷调查等方法,运用标准化研究工具进行。慢性病依从量表(ACDS)用于评估对治疗建议的依从程度。采用扩展残疾状态量表(EDSS)评估残疾程度,采用改良疲劳影响量表(MFIS)评估残疾程度。使用卡方检验、Shapiro-Wilk 检验和 Kruskal-Wallis 检验。结果:统计分析表明,EDSS 量表中评估的患者运动障碍与 ACDS 量表中评估的治疗建议的依从性水平之间存在相关性 (p=0.0055)。患者的残疾程度越高(EDSS 4.5-6.5),治疗依从率越低。进行的研究表明,在 MFIS 量表中,个人遵守 ACDS 量表中表达的治疗建议的平均分分别为:低水平 - 38.3 MFIS 分,中水平 - 34.4 MFIS 分,高水平 - 34.4 MFIS 分。级别 - 33.2 MFIS 点。获得的结果没有统计学意义(p=0.6098)。结论:发现研究组中接受免疫调节治疗的复发缓解型多发性硬化症患者对治疗建议的依从性仍然很高。患者的残疾与对治疗建议的遵守程度之间存在关系。
更新日期:2021-08-27
down
wechat
bug