当前位置: X-MOL 学术Int. J. Med. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Plasma levels of amino acids and derivatives in retinopathy of prematurity.
International Journal of Medical Sciences ( IF 3.6 ) Pub Date : 2021-08-27 , DOI: 10.7150/ijms.63603
Yedi Zhou 1, 2 , Yu Xu 3 , Xiang Zhang 3 , Qian Huang 1, 2 , Wei Tan 1, 2 , Yonghui Yang 4 , Xiaori He 4 , Shigeo Yoshida 5 , Peiquan Zhao 3 , Yun Li 1, 2
Affiliation  

Background: Retinopathy of prematurity (ROP) is a retinal disease that causes blindness in premature infants. This study aimed to reveal the changes in amino acids and derivatives in the plasma of ROP patients compared with premature infants without ROP. Methods: Metabolomics targeting amino acids and their derivatives was conducted to assess their plasma levels in ROP patients (n=58) and premature infants without ROP (n=25), and KEGG pathway analysis was used to identify the involved pathways. Results: Among the 31 assessed metabolites, the levels of 4 amino acids were significantly altered in the ROP group. Creatinine was downregulated in the plasma of the ROP patients, while the levels of citrulline, arginine, and aminoadipic acid were upregulated in the ROP group. Significant correlations were identified between the ROP stage and plasma levels of citrulline, creatinine, and aminoadipic acid. The involved pathways included biosynthesis of amino acids, arginine and proline metabolism, and arginine biosynthesis. Conclusion: The plasma levels of citrulline, creatinine, arginine, and aminoadipic acid were significantly changed in ROP patients. These metabolites could be considered potential biomarkers of ROP, and their related metabolic pathways might be involved in ROP pathogenesis.

中文翻译:

早产儿视网膜病变中氨基酸和衍生物的血浆水平。

背景:早产儿视网膜病变(ROP)是一种导致早产儿失明的视网膜疾病。本研究旨在揭示与无ROP早产儿相比,ROP患者血浆中氨基酸及其衍生物的变化。方法:针对氨基酸及其衍生物进行代谢组学,以评估其在 RO​​P 患者(n=58)和无 ROP 早产儿(n=25)中的血浆水平,并使用 KEGG 通路分析识别相关通路。结果:在评估的 31 种代谢物中,ROP 组中 4 种氨基酸的水平发生了显着变化。ROP 患者血浆中的肌酐水平下调,而 ROP 组的瓜氨酸、精氨酸和氨基己二酸水平上调。ROP 阶段与血浆瓜氨酸、肌酐和氨基己二酸水平之间存在显着相关性。涉及的途径包括氨基酸的生物合成、精氨酸和脯氨酸的代谢以及精氨酸的生物合成。结论:ROP患者血浆瓜氨酸、肌酐、精氨酸和氨基己二酸水平发生显着变化。这些代谢物可以被认为是ROP的潜在生物标志物,它们的相关代谢途径可能参与了ROP的发病机制。
更新日期:2021-08-27
down
wechat
bug