OBJECTIVES Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown. METHODS Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated. RESULTS We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events. CONCLUSIONS A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.

中文翻译：

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经皮冠状动脉介入治疗后稳定型冠状动脉疾病患者血浆黄嘌呤氧化还原酶活性与院内结局的相关性。

目的 黄嘌呤氧化还原酶 (XOR) 产生的活性氧与动脉粥样硬化的进展有关。然而，稳定型冠状动脉疾病 (CAD) 经皮冠状动脉介入治疗 (PCI) 后血浆 XOR (pXOR) 活性的变化仍然未知。方法在此，我们比较了接受 PCI 的患者与接受冠状动脉造影 (CAG) 患者的 pXOR 活性的变化，并进一步评估了 pXOR 活性的变化与接受 PCI 的患者的院内和长期结果之间的关系。每天对住院期间接受 PCI 的 80 名患者和接受 CAG 的 25 名患者的 pXOR 活性进行分析。评估了从基线调节时间间隔的百分比变化。结果 我们发现虽然 PCI 后 pXOR 活性降低，在出院前一直保持低水平，在接受 CAG 的患者中没有观察到显着变化。此外，在接受 PCI 的患者中，经历过院内不良事件的患者在 PCI 后 3 天的 pXOR 降低百分比更高。这些变化与长期事件之间没有关联。结论 与接受 CAG 的患者相比，在接受 PCI 的患者中观察到 pXOR 活性的显着变化，并且住院结果与 pXOR 活性从基线降低的百分比之间似乎存在相关性。这些变化与长期事件之间没有关联。结论 与接受 CAG 的患者相比，在接受 PCI 的患者中观察到 pXOR 活性的显着变化，并且住院结果与 pXOR 活性从基线降低的百分比之间似乎存在相关性。这些变化与长期事件之间没有关联。结论 与接受 CAG 的患者相比，在接受 PCI 的患者中观察到 pXOR 活性的显着变化，并且住院结果与 pXOR 活性从基线降低的百分比之间似乎存在相关性。