The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts participate in the bone remodelling process under the regulation of various factors inside and outside. Excessive activation of osteoclasts or lack of function of osteoblasts will cause occurrence and development of multiple bone-related diseases. Ca²⁺/Calcineurin/NFAT signalling pathway regulates the growth and development of many types of cells, such as cardiomyocyte differentiation, angiogenesis, chondrogenesis, myogenesis, bone development and regeneration, etc. Some evidences indicate that this signalling pathway plays an extremely important role in bone formation and bone pathophysiologic changes. This review discusses the role of Ca²⁺/Calcineurin/NFAT signalling pathway in the process of osteogenic differentiation, as well as the influence of regulating each component in this signalling pathway on the differentiation and function of osteoblasts, whereby the relationship between Ca²⁺/Calcineurin/NFAT signalling pathway and osteoblastogenesis could be deeper understood.

中文翻译：

---

Ca2+/Calcineurin/NFAT 信号通路在成骨细胞发生中的作用

骨骼重塑过程与骨骼健康密切相关。成骨细胞和破骨细胞在内外多种因素的调控下参与骨重塑过程。破骨细胞过度活化或成骨细胞功能缺失会导致多种骨相关疾病的发生和发展。Ca ²⁺ /Calcineurin/NFAT 信号通路调控多种类型细胞的生长发育，如心肌细胞分化、血管生成、软骨形成、肌生成、骨发育和再生等。有证据表明该信号通路起着极其重要的作用骨形成和骨病理生理变化。本综述讨论了 Ca ²⁺的作用/Calcineurin/NFAT信号通路在成骨分化过程中的作用，以及调控该信号通路中各组分对成骨细胞分化和功能的影响，由此Ca ²⁺ /Calcineurin/NFAT信号通路与成骨细胞发生的关系得到更深的理解。