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Cashing in on ferroptosis against tumor cells: Usher in the next chapter
Life Sciences ( IF 6.1 ) Pub Date : 2021-09-14 , DOI: 10.1016/j.lfs.2021.119958
Mehdi Rabiee Valashedi 1 , Nima Najafi-Ghalehlou 2 , Amirsadegh Nikoo 1 , Chia Bamshad 1 , Kazuo Tomita 3 , Yoshikazu Kuwahara 4 , Tomoaki Sato 3 , Amaneh Mohammadi Roushandeh 5 , Mehryar Habibi Roudkenar 6
Affiliation  

Ferroptosis is a new type of non-apoptotic regulated cell death (RCD) driven by unrestricted lethal lipid peroxidation, which is totally distinct from other forms of RCD in genetic and biochemical characteristics. It is generally believed that iron dependency, malfunction of the redox system, and excessive lipid peroxidation are the main hallmarks of ferroptosis. Accumulating pieces of evidence over the past few years have shown that ferroptosis is tightly related to various types of diseases, especially cancers. Ferroptosis has recently attracted great attention in the field of cancer research. A plethora of evidence shows that employing ferroptosis as a powerful weapon can remarkably enhance the efficacy of tumor cell annihilation. Better knowledge of the ferroptosis mechanisms and their interplay with cancer biology would enable us to use this fashionable tool in the best way. Herein, we will briefly present the relevant mechanisms of ferroptosis, the multifaceted relation between ferroptosis and cancer, encompassing tumor immunity, overcoming chemoresistance, and epithelial to mesenchymal transition. In the end, we will also briefly discuss the potential approaches to ferroptosis-based cancer therapy, such as using drugs and small molecules, nanoparticles, mitochondrial targeting, and photodynamic therapy.



中文翻译:

利用针对肿瘤细胞的铁死亡:迎接下一章

Ferroptosis是一种由不受限制的致死脂质过氧化驱动的新型非凋亡调节细胞死亡(RCD),在遗传和生化特征上与其他形式的RCD完全不同。一般认为铁依赖、氧化还原系统功能障碍和脂质过氧化过度是铁死亡的主要标志。过去几年积累的证据表明,铁死亡与各种疾病,尤其是癌症密切相关。铁死亡最近在癌症研究领域引起了极大的关注。大量证据表明,将铁死亡作为一种强大的武器,可以显着提高杀伤肿瘤细胞的功效。更好地了解铁死亡机制及其与癌症生物学的相互作用将使我们能够以最佳方式使用这种时尚工具。在此,我们将简要介绍铁死亡的相关机制、铁死亡与癌症之间的多方面关系,包括肿瘤免疫、克服化学耐药性和上皮向间质转化。最后,我们还将简要讨论基于铁死亡的癌症治疗的潜在方法,例如使用药物和小分子、纳米粒子、线粒体靶向和光动力治疗。

更新日期:2021-09-17
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