Objective

Alkali treatment and bioactive glass (BG) sol dip-coating are well-known individual methods for titanium (Ti) surface modification. In this study, a unique combination of alkali treatment and bioactive glass sol dip coating was applied to the Ti substrate, then the mechanical properties and cell responses were investigated.

Methods

Based on the methods introduced above, the Ti substrate was treated by 6 mL of an NaOH 5 M aqueous solution for 24 h at 60 ̊C; this was followed by adding 1.2 mL of a BG 58S sol to form a novel combined nanostructure network covered by a thin BG layer. For the assessment of the formed coating layer, the morphology, elemental analysis, phase structure, adhesion property and the cell response of the untreated and treated surfaces were investigated.

Results

The BG coating layer was reinforced by the nanostructure, fabricated through the alkali treatment. The results obtained by applying the combined modification method confirmed that the mechanical and biological properties of the fabricated surface demonstrated the highest performance compared to that of the unmodified and individually modified surfaces.

Significance

The achieved upgrades for this method could be gained from the demanded porous nanostructure and the apatite transformation ability of the alkali treatment. Therefore, the hybridized application of the alkali-BG treatment could be introduced as a promising surface modification strategy for hard-tissue replacement applications.

中文翻译：

---

利用碱溶液和生物活性玻璃溶胶组合对钛植入物进行新型多结构增强处理

客观的

碱处理和生物活性玻璃 (BG) 溶胶浸涂是众所周知的钛 (Ti) 表面改性方法。在这项研究中，将碱处理和生物活性玻璃溶胶浸涂的独特组合应用于 Ti 基材，然后研究了机械性能和电池响应。

方法

基于以上介绍的方法，将Ti基板用6mL NaOH 5M水溶液在60°C下处理24小时；然后加入 1.2 mL BG 58S 溶胶，形成一种新型复合纳米结构网络，并覆盖有薄 BG 层。为了评估形成的涂层，研究了未处理和处理表面的形态、元素分析、相结构、粘附性能和细胞响应。

结果

通过碱处理制造的纳米结构增强了BG涂层。通过应用组合改性方法获得的结果证实，与未改性和单独改性的表面相比，制造表面的机械和生物特性表现出最高的性能。

意义

该方法所实现的升级可以从所需的多孔纳米结构和碱处理的磷灰石转化能力中获得。因此，碱-BG 处理的杂交应用可以作为硬组织置换应用的一种有前景的表面改性策略。