Emergence of IncX3 Plasmid-Harboring blaNDM-5 in a Citrobacter sedlakii Isolated from Outdoor Aerosol in Wastewater Treatment Plant,Microbial Drug Resistance

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Emergence of IncX3 Plasmid-Harboring blaNDM-5 in a Citrobacter sedlakii Isolated from Outdoor Aerosol in Wastewater Treatment Plant
Microbial Drug Resistance ( IF 2.6 ) Pub Date : 2022-02-14 , DOI: 10.1089/mdr.2021.0057
Ziyu Zhou ₁ , Björn Berglund ₂ , Jiaqi Liu ₁ , Ling Zhao ₁ , Huiyu Xia ₁ , Huiyun Zou ₁ , Qian Zhao ₁ , Xuewen Li ₁

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A carbapenem-resistant Citrobacter sedlakii strain AA2CS carrying bla_NDM-5 was detected in outdoor aerosols of a wastewater treatment plant (WWTP) in China and the whole genome was sequenced subsequently. AA2CS was captured in an aerobic tank with aerosol particles of sizes ranging from 4.7 to 7.0 μm. Besides bla_NDM-5, AA2CS also harbored 21 other antibiotic resistance genes and displayed a high level of resistance to ampicillin, cefotaxime, ceftazidime, tetracycline, and meropenem. Bla_NDM-5 was located on the IncX3 plasmid (pCSNDM-5) with an IS3000-IS5-bla_NDM-5-ble_MBL-trpF-dsbD-IS26 structure. pCSNDM-5 was highly homologous to other bla_NDM-5-carrying IncX3 plasmids in China and can be transferred to the Escherichia coli recipient J53. To our knowledge, this is the first report of carbapenem-resistant Enterobacteriaceae in outdoor aerosols in WWTPs.

更新日期：2022-02-14

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