Surfaces and Interfaces ( IF 6.2 ) Pub Date : 2021-09-15 , DOI: 10.1016/j.surfin.2021.101460 Muhammad Ayub 1 , Mohd Hafiz Dzarfan Othman 1 , Imran Ullah Khan 2 , Mohd Zamri Mohd Yusop 1 , Tonni Agustiono Kurniawan 3
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a significant and topmost global health challenge of today. SARS-CoV-2 can propagate through several direct or indirect means resulting in its exponential spread in short times. Consequently, finding new research based real-world and feasible solutions to interrupt the spread of pathogenic microorganisms is indispensable. It has been established that this virus can survive on a variety of available surfaces ranging from a few hours to a few days, which has increased the risk of COVID-19 spread to large populations. Currently, available surface disinfectant chemicals provide only a temporary solution and are not recommended to be used in the long run due to their toxicity and irritation. Apart from the urgent development of vaccine and antiviral drugs, there is also a need to design and develop surface disinfectant antiviral coatings for long-term applications even for new variants. The unique physicochemical properties of graphene-based nanomaterials (GBNs) have been widely investigated for antimicrobial applications. However, the research work for their use in antimicrobial surface coatings is minimal. This perspective enlightens the scope of using GBNs as antimicrobial/antiviral surface coatings to reduce the spread of transmittable microorganisms, precisely, SARS-CoV-2. This study attempts to demonstrate the synergistic effect of GBNs and metallic nanoparticles (MNPs), for their potential antiviral applications in the development of surface disinfectant coatings. Some proposed mechanisms for the antiviral activity of the graphene family against SARS-CoV-2 has also been explained. It is anticipated that this study will potentially lead to new insights and future trends to develop a framework for further investigation on this research area of pivotal importance to minimize the transmission of current and any future viral outbreaks.
中文翻译:
石墨烯基纳米材料作为抗菌表面涂层:抑制 COVID-19 扩张的并行方法
最近出现的严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 已成为当今全球最重要的健康挑战。SARS-CoV-2 可以通过多种直接或间接方式传播,导致其在短时间内呈指数级传播。因此,寻找基于现实世界的新研究和可行的解决方案来阻止病原微生物的传播是必不可少的。现已确定,这种病毒可以在各种可用的表面上存活数小时到几天,这增加了 COVID-19 传播给大量人群的风险。目前,可用的表面消毒化学品只能提供临时解决方案,由于其毒性和刺激性,不建议长期使用。除了迫切开发疫苗和抗病毒药物外,还需要设计和开发表面消毒抗病毒涂层以供长期应用,甚至是新变种。石墨烯基纳米材料(GBN)独特的理化性质已被广泛研究用于抗菌应用。然而,其在抗菌表面涂层中的应用研究工作却很少。这一观点启发了使用 GBN 作为抗菌/抗病毒表面涂层来减少可传播微生物(确切地说,SARS-CoV-2)传播的范围。本研究试图证明 GBN 和金属纳米粒子 (MNP) 的协同效应,及其在表面消毒涂层开发中潜在的抗病毒应用。石墨烯家族针对 SARS-CoV-2 的抗病毒活性的一些拟议机制也已得到解释。预计这项研究将有可能带来新的见解和未来趋势,以开发一个框架,进一步研究这一至关重要的研究领域,以最大限度地减少当前和任何未来病毒爆发的传播。