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Taurine and Camel Milk Modulate Neurobehavioral and Biochemical Changes in Aluminum Chloride-Induced Alzheimer’s Disease in Rats
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-10 , DOI: 10.3233/jad-210130
Teslim S Abdulkadir 1 , Fatima A Dawud 1 , Ahmed Sherif Isa 1 , Joseph O Ayo 2
Affiliation  

Background:Alzheimer’s disease (AD) is a neurodegenerative disease associated with deficiency in motor coordination, cognitive impairment, and excessive reactive oxygen species production in the brain. Objective:The study evaluated effects of taurine and camel milk (CM) on neurobehavior, amyloid-beta peptide 1–42 (Aβ) expression, acetylcholinesterase, and superoxide dismutase activities in aluminum chloride (AlCl3) model of Alzheimer’s disease in rats. Methods:Thirty-five female Wistar rats were divided into seven groups (n = 5): Normal saline (0.2 mL/kg body weight); AlCl3 (100 mg/kg) (AD); CM (33 mL/kg); Taurine (50 mg/kg); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg); and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). The administration lasted for eight weeks via oral gavage. After the eighth week, neurobehavior assessments were performed. Rats were sacrificed, and brain and blood samples collected for analysis. Results:There was a significant (p < 0.0001) increase in the duration of motor endurance in AD + CM rats, compared to AD rats. Duration of forced swimming time was lowest (p < 0.0001) in AlCl3 + Taurine rats, compared to that of AD rats. Concentration of Aβ peptide decreased (p < 0.05) in AD rats, treated with CM and/or combination. In taurine-treated rats, superoxide dismutase activity was significantly (p < 0.05) higher than in AD rats. Treatment with taurine + CM increased (p < 0.05) acetylcholinesterase activity compared to controls. Conclusion:Taurine and CM enhanced cognition and sensorimotor activity by decreasing Aβ peptide concentration and increasing superoxide dismutase and acetylcholinesterase activities in AD rats.

中文翻译:

牛磺酸和骆驼奶调节氯化铝诱导的大鼠阿尔茨海默病的神经行为和生化变化

背景:阿尔茨海默病 (AD) 是一种神经退行性疾病,与运动协调性缺陷、认知障碍和大脑中过量的活性氧产生有关。目的:该研究评估了牛磺酸和骆驼奶 (CM) 对阿尔茨海默病大鼠氯化铝 (AlCl3) 模型中神经行为、淀粉样蛋白 β 肽 1-42 (Aβ) 表达、乙酰胆碱酯酶和超氧化物歧化酶活性的影响。方法:35只雌性Wistar大鼠分为7组(n=5):生理盐水(0.2mL/kg体重);AlCl3 (100 mg/kg) (AD);厘米 (33 毫升/公斤); 牛磺酸 (50 毫克/公斤); AlCl3 (100 mg/kg) + CM (33 mL/kg);三氯化铝 (100 毫克/公斤) + 牛磺酸 (50 毫克/公斤); 和 AlCl3 (100 mg/kg) + CM (33 mL/kg) + 牛磺酸 (50 mg/kg)。通过口服管饲给药持续八周。第八周之后,进行了神经行为评估。处死大鼠,收集脑和血样用于分析。结果:与 AD 大鼠相比,AD + CM 大鼠的运动耐力持续时间显着增加(p < 0.0001)。与 AD 大鼠相比,AlCl3 + 牛磺酸大鼠的强迫游泳时间最短 (p < 0.0001)。在用 CM 和/或组合治疗的 AD 大鼠中,Aβ 肽的浓度降低(p < 0.05)。在牛磺酸治疗的大鼠中,超氧化物歧化酶活性显着(p < 0.05)高于 AD 大鼠。与对照相比,用牛磺酸 + CM 处理增加 (p < 0.05) 乙酰胆碱酯酶活性。结论:
更新日期:2021-09-15
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