The chromatin landscape represents a critical regulatory layer for precise transcriptional control. Chromosome architecture restrains the physical access to the DNA elements and is one of the determinants that specifies cell identity. Adult stem cells possess the unique ability to differentiate into a specific lineage. One of the underexplored areas in skeletal muscle biology is the molecular mechanism guiding the chromatin organization changes in muscle stem cell specification, myogenic determination, and differentiation. In this review, we focus on the regulatory network guiding the progression of muscle stem cells to differentiated progeny. We summarize recent findings regarding the mechanisms directing myogenic cell fate decision and differentiation, with a particular focus on three-dimensional chromosome architecture and long noncoding RNA-associated chromatin accessibility changes.

染色质景观代表了精确转录控制的关键调控层。染色体结构限制了对 DNA 元素的物理访问，并且是指定细胞身份的决定因素之一。成体干细胞具有分化成特定谱系的独特能力。骨骼肌生物学中未充分探索的领域之一是指导肌肉干细胞规格、肌原性决定和分化中染色质组织变化的分子机制。在这篇综述中，我们专注于指导肌肉干细胞向分化后代进展的调控网络。我们总结了有关指导肌源性细胞命运决定和分化的机制的最新发现，