Objectives

Diabetes appears to decrease the risk of subarachnoid hemorrhage. However, it is not clear whether diabetes decreases the risk of aneurysm formation. The aim of our study to evaluate the risk of unruptured cerebral aneurysm in patients with diabetes mellitus.

Methods

We used data from participants who underwent brain magnetic resonance angiography (MRA) and laboratory tests at the Healthcare System Gangnam Center of Seoul National University Hospital between January 2010 and December 2013. From the 17,368 participants who underwent brain MRA, we analyzed 16,337 subjects whose diabetes status could be identified.

Results

The number of participants with diabetes was 2299 (14.1%). The proportion of participants with cerebral aneurysms was 2.3% in the diabetic group and 2.7% in the non-diabetic group, which was not significantly different (P = 0.225). There were no significant differences in the size, location, and multiplicity of aneurysms between the diabetes and control groups. In multivariate logistic regression, older age showed significant risk effects on cerebral aneurysms, but female sex, hypertension, diabetes, obesity, and smoking did not show significant risk effects.

Conclusion

In this study, diabetes did not affect the risk of cerebral aneurysm formation. In addition, neither smoking, nor hypertension was a significant risk factor for unruptured cerebral aneurysms. The lack of association between cerebral aneurysm and the traditional risk factors for subarachnoid hemorrhage requires further study. Risk factors for cerebral aneurysm development and those for cerebral aneurysm rupture may be different.

中文翻译：

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糖尿病对未破裂脑动脉瘤的形成没有保护作用

目标

糖尿病似乎可以降低蛛网膜下腔出血的风险。然而，尚不清楚糖尿病是否会降低动脉瘤形成的风险。我们研究的目的是评估糖尿病患者未破裂脑动脉瘤的风险。

方法

我们使用了 2010 年 1 月至 2013 年 12 月期间在首尔国立大学医院医疗保健系统江南中心接受脑磁共振血管造影 (MRA) 和实验室检查的参与者的数据。从接受脑 MRA 的 17,368 名参与者中，我们分析了 16,337 名患有糖尿病的受试者可以识别状态。

结果

糖尿病患者人数为 2299 人（14.1%）。糖尿病组患脑动脉瘤的比例为2.3%，非糖尿病组为2.7%，差异无统计学意义（P  =0.225）。糖尿病组和对照组之间动脉瘤的大小、位置和多发性没有显着差异。在多变量逻辑回归中，年龄较大对脑动脉瘤有显着的风险影响，但女性、高血压、糖尿病、肥胖和吸烟没有显示出显着的风险影响。

结论

在这项研究中，糖尿病不影响脑动脉瘤形成的风险。此外，吸烟和高血压都不是未破裂脑动脉瘤的重要危险因素。脑动脉瘤与蛛网膜下腔出血的传统危险因素之间缺乏关联需要进一步研究。脑动脉瘤发展的危险因素和脑动脉瘤破裂的危险因素可能不同。