Cell Reports ( IF 8.8 ) Pub Date : 2021-09-14 , DOI: 10.1016/j.celrep.2021.109661 Dustin Fetterhoff 1 , Andrey Sobolev 1 , Christian Leibold 2
Hippocampal place cells are thought to constitute a cognitive map of space derived from multimodal sensory inputs. Alteration of allocentric (visual) cues in a fixed environment is known to induce modulations of place cell activity to varying degrees from rate changes to global remapping. To determine how hippocampal ensembles combine multimodal sensory cues, we examine hippocampal CA1 remapping in Mongolian gerbils in a 1D virtual reality experiment, during which self-motion cues (locomotor, vestibular, and optic flow information) and allocentric visual cues are altered. We observe that self-motion cues are over-represented, but responsiveness to allocentric visual cues, although task-irrelevant, elicits both rate and global remapping in the hippocampal ensemble. We propose that remapping can be reconciled by considering global, partial, and rate remapping on a continuous scale on which the graded change of activity in the entire CA1 population can be interpreted as the expectancy about the animal’s spatial environment.
中文翻译:
感觉冲突下海马集合的分级重映射
海马位置细胞被认为构成了来自多模式感觉输入的空间认知图。已知在固定环境中改变异中心(视觉)线索会在不同程度上诱导位置细胞活动的调节,从速率变化到全局重新映射。为了确定海马集合如何结合多模态感觉线索,我们在 1D 虚拟现实实验中检查了蒙古沙鼠的海马 CA1 重新映射,在此期间,自运动线索(运动、前庭和光流信息)和异中心视觉线索发生了变化。我们观察到自运动线索被过度代表,但对异中心视觉线索的反应,虽然与任务无关,但在海马体中引起速率和全局重新映射。我们建议重新映射可以通过考虑全局、部分、