当前位置:
X-MOL 学术
›
Int. J. Nanomed.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2021-09-15 , DOI: 10.2147/ijn.s279192 Tao Lu 1 , Jai Prakash 1
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2021-09-15 , DOI: 10.2147/ijn.s279192 Tao Lu 1 , Jai Prakash 1
Affiliation
Abstract: Pancreatic cancer is one of the most malignant tumors with one of the worst survival rates due to its insidious onset and resistance to therapies. Most therapeutics show a desired anticancer effect in vitro; however, very poor efficacy in vivo because of the limited drug delivery and penetration into pancreatic tumors attributed to the abundance of the tumor stroma, ie, the fibrotic tumor microenvironment surrounding the cancer cells. For a better understanding of the challenges posed by the pancreatic tumor stroma, we outline the key features of the tumor microenvironment. Then we highlight major strategies used to tackle the challenges to improve drug penetration into the tumor and achieve enhanced efficacy (pre)clinically. Furthermore, we describe nanomedicine strategies to modulate the tumor stroma, degrade the extracellular matrix, and co-deliver multi-functional drugs, to improve the chemotherapeutics delivery and penetration into pancreatic tumors.
Keywords: pancreatic ductal adenocarcinoma, cancer-associated fibroblasts, tumor stroma, tumor vasculature, drug perfusion, drug penetration
中文翻译:
增强胰腺癌肿瘤药物渗透的纳米医学策略
摘要:胰腺癌是最恶性的肿瘤之一,由于其起病隐匿和对治疗的抵抗力最差,因此是生存率最差的肿瘤之一。大多数疗法在体外显示出所需的抗癌效果;然而,由于肿瘤基质丰富,即癌细胞周围的纤维化肿瘤微环境,药物递送和渗透到胰腺肿瘤中的能力有限,因此在体内的疗效非常差。为了更好地了解胰腺肿瘤基质带来的挑战,我们概述了肿瘤微环境的关键特征。然后,我们重点介绍了用于应对挑战的主要策略,以改善药物对肿瘤的渗透并在临床前(前)实现增强的疗效。此外,我们描述了调节肿瘤基质、降解细胞外基质、
关键词:胰腺导管腺癌,癌症相关成纤维细胞,肿瘤基质,肿瘤血管,药物灌注,药物渗透
更新日期:2021-09-15
Keywords: pancreatic ductal adenocarcinoma, cancer-associated fibroblasts, tumor stroma, tumor vasculature, drug perfusion, drug penetration
中文翻译:
增强胰腺癌肿瘤药物渗透的纳米医学策略
摘要:胰腺癌是最恶性的肿瘤之一,由于其起病隐匿和对治疗的抵抗力最差,因此是生存率最差的肿瘤之一。大多数疗法在体外显示出所需的抗癌效果;然而,由于肿瘤基质丰富,即癌细胞周围的纤维化肿瘤微环境,药物递送和渗透到胰腺肿瘤中的能力有限,因此在体内的疗效非常差。为了更好地了解胰腺肿瘤基质带来的挑战,我们概述了肿瘤微环境的关键特征。然后,我们重点介绍了用于应对挑战的主要策略,以改善药物对肿瘤的渗透并在临床前(前)实现增强的疗效。此外,我们描述了调节肿瘤基质、降解细胞外基质、
关键词:胰腺导管腺癌,癌症相关成纤维细胞,肿瘤基质,肿瘤血管,药物灌注,药物渗透