ABSTRACT

Background

Primary hypertension is one of the most well-known risk factors for cardiovascular disease. Currently, there is still no ideal indicator for left ventricular end-diastolic pressure.

Methods

73 hypertension patients and 37 healthy people were enrolled in this study. Each member was examined with conventional echocardiography including multiple indicators such as Peak mitral valve flow velocity (E, A), E/A, left atrial volume index (LAVl), tissue Doppler (PW-TDI) peak velocities during early and late diastolic mitral valve flow (e ‘), E/e ‘, and GLS. We have collected clinical data from all enrolled members. The above cardiac ultrasound indicators were obtained before the antihypertensive treatment, one month and three months after treatment.

Results

Left ventricular end-diastolic pressure (LVEDP) was positively correlated and negatively correlated with GLS (r = 0.638, P < .01) and E/e’ (r = −0.578, P < .05), respectively. The hypertensives had lower e’ value and higher values of GLS, E/e’, and LAVI than the control group (P < .05). GLS and E/e’ were significantly lower in hypertension group than those in the Control group after one month and three months of treatment (P < .05). The improvement rate of GLS was significantly higher than those in the improvement rate of e’, E/e’, LAVI after treatment (p < .05).

Conclusion

The GLS improvement rate was significantly higher than those of e’, E/e’ after one and three-month treatment. Therefore, GLS might be a potential ideal index for patients with anti-hypertension treatment. The results obtained in this study provide useful information for further study.

中文翻译：

---

左心室长轴超声应变（GLS）是患者抗高血压治疗的理想指标

摘要

背景

原发性高血压是心血管疾病最著名的危险因素之一。目前，左心室舒张末期压仍没有理想的指标。

方法

73名高血压患者和37名健康人参加了本研究。使用常规超声心动图检查每个成员，包括多种指标，例如二尖瓣峰值流速 (E, A)、E/A、左心房容积指数 (LAVl)、组织多普勒 (PW-TDI) 舒张早期和晚期二尖瓣峰值速度阀门流量 (e')、E/e' 和 GLS。我们收集了所有注册会员的临床数据。上述心脏超声指标在降压治疗前、治疗后1个月和3个月获得。

结果

左心室舒张末期压力 (LVEDP) 分别与 GLS (r = 0.638, P < .01) 和 E/e' (r = -0.578, P < .05) 呈正相关和负相关。高血压患者e'值低于对照组，GLS、E/e'、LAVI值高于对照组（P <.05）。高血压组治疗1个月和3个月后GLS和E/e'明显低于对照组（P <0.05）。GLS的改善率明显高于e'、E/e'、LAVI治疗后的改善率（p < .05）。

结论

治疗1个月和3个月后GLS改善率明显高于e'、E/e'。因此，GLS可能是患者抗高血压治疗的潜在理想指标。本研究获得的结果为进一步研究提供了有用的信息。