Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.

中文翻译：

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免疫印迹和 SARS-CoV-2 疫苗设计

正在寻求用变异株重新配制严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 疫苗，以应对全球感染激增。我们假设这可能是次优的，因为早期疫苗接种或感染原始 SARS-CoV-2 菌株的免疫印记。可能需要新的策略来提高 SARS-CoV-2 变异疫苗的功效。