A mild and facile synthetic method via convergent assembly of two reactive intermediates generated in situ has been developed. This method provides an efficient way to construct six- and seven-membered N-heterocycles containing a biaryl linkage. This reaction features a gem-difunctionalization process of diazo compounds with cyclic hemiaminals, delivering α-hydroxyl-β-amino ester derivatives with a tertiary carbon center through a formal C–O bond-insertion transformation.

中文翻译：

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Rh(II)-或Ag(I)-催化的环状半缩醛与重氮乙酸芳基酯的形式C-O键插入

已经开发了一种通过原位生成的两种反应中间体的会聚组装的温和简便的合成方法。该方法提供了一种构建含有联芳基键的六元和七元 N-杂环的有效方法。该反应的特点是重氮化合物与环状半缩醛的双功能化过程，通过正式的 C-O 键插入转化，提供具有叔碳中心的 α-羟基-β-氨基酯衍生物。