### [Puhalla et al. Page 4983][1] Advanced breast cancers associated with germline breast cancer susceptibility gene (g BRCA ) mutations are sensitive to platinum chemotherap. and poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi). However, shared mechanisms of acquired resistance to

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### [普哈拉等人。第 4983 页][1] 与生殖系乳腺癌易感基因 (g BRCA ) 突变相关的晚期乳腺癌对铂化疗敏感。和聚（二磷酸腺苷 - 核糖）聚合酶抑制剂（PARPi）。然而，获得性抗药性的共同机制