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Biocompatible Ruthenium Single-Atom Catalyst for Cascade Enzyme-Mimicking Therapy
ACS Applied Materials & Interfaces ( IF 9.5 ) Pub Date : 2021-09-14 , DOI: 10.1021/acsami.1c12706
Wenyu Wang 1 , Yang Zhu 2 , Xiaorong Zhu 3 , Yafei Zhao 1 , Zhenggang Xue 1 , Can Xiong 1 , Zhiyuan Wang 1 , Yunteng Qu 1 , Junjie Cheng 2 , Min Chen 1 , Manman Liu 2 , Fangyao Zhou 1 , Haoran Zhang 1 , Zheng Jiang 4 , Yidong Hu 1 , Huang Zhou 1 , Huijuan Wang 5 , Yafei Li 3 , Yangzhong Liu 2 , Yuen Wu 1, 6
Affiliation  

Rationally constructing single-atom enzymes (SAEs) with superior activity, robust stability, and good biocompatibility is crucial for tumor therapy but still remains a substantial challenge. In this work, we adopt biocompatible carbon dots as the carrier material to load Ru single atoms, achieving Ru SAEs with superior multiple enzyme-like activity and stability. Ru SAEs behave as oxidase, peroxidase, and glutathione oxidase mimics to synchronously catalyze the generation of reactive oxygen species (ROS) and the depletion of glutathione, thus amplifying the ROS damage and finally causing the death of cancer cells. Notably, Ru SAEs exhibit excellent peroxidase-like activity with a specific activity of 7.5 U/mg, which surpasses most of the reported SAEs and is 20 times higher than that of Ru/C. Theoretical results reveal that the electrons of the Ru 4d orbital in Ru SAEs are transferred to O atoms in H2O2 and then efficiently activate H2O2 to produce OH. Our work may provide some inspiration for the design of SAEs for cancer therapy.

中文翻译:

用于级联酶模拟疗法的生物相容性钌单原子催化剂

合理构建具有优异活性、稳健稳定性和良好生物相容性的单原子酶(SAE)对于肿瘤治疗至关重要,但仍然是一项重大挑战。在这项工作中,我们采用生物相容性碳点作为载体材料负载钌单原子,实现了具有优异的多酶活性和稳定性的钌 SAE。Ru SAEs表现为氧化酶、过氧化物酶和谷胱甘肽氧化酶模拟物,同步催化活性氧(ROS)的产生和谷胱甘肽的消耗,从而放大ROS损伤并最终导致癌细胞死亡。值得注意的是,Ru SAEs 表现出优异的过氧化物酶样活性,比活性为 7.5 U/mg,超过了大多数已报道的 SAEs,比 Ru/C 高 20 倍。2 O 2然后有效地激活H 2 O 2产生 OH。我们的工作可能为设计用于癌症治疗的 SAE 提供一些启发。
更新日期:2021-09-29
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