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Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing
Stem Cells International ( IF 4.3 ) Pub Date : 2021-09-15 , DOI: 10.1155/2021/1285087
Jianghong Huang 1, 2 , Jun Zhang 2 , Jianyi Xiong 1 , Shuqing Sun 3 , Jiang Xia 4 , Lei Yang 1 , Yujie Liang 5
Affiliation  

Wound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. Mesenchymal stem cells participate in the recruitment site, mainly by releasing secretory factors and matrix proteins to promote wound healing. Stem cell-derived nanovesicles (CDNs), including microvesicles, exosomes, and exosome mimetics, contain most of the biologically active substances of their parent cells and have similar effects. CDNs can shuttle various proteins, messenger RNAs, and microRNAs to regulate the activity of receptor cells, and they play important roles in skin wound healing. This article reviews recent research progress on CDNs for wound repair. We summarize current knowledge on how CDNs regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process. This review can help researchers explore new treatment strategies to enhance the therapeutic efficacy of CDNs, which have a promising future as naturally cell-free therapies.

中文翻译:

干细胞衍生的纳米囊泡:一种用于伤口愈合的新型无细胞疗法

伤口愈合和再生是一个动态和复杂的过程,需要生长因子、表皮细胞、真皮细胞、细胞外基质和伤口区域局部血管之间的协作努力。间充质干细胞参与募集部位,主要通过释放分泌因子和基质蛋白来促进伤口愈合。干细胞衍生的纳米囊泡(CDN),包括微囊泡、外泌体和外泌体模拟物,含有其母细胞的大部分生物活性物质,并具有相似的作用。CDNs可以穿梭各种蛋白质、信使RNA和microRNAs来调节受体细胞的活性,在皮肤伤口愈合中发挥着重要作用。本文综述了近年来CDNs用于伤口修复的研究进展。我们总结了当前关于 CDN 如何调节免疫的知识,成纤维细胞活性、血管生成和伤口愈合过程中的疤痕形成。该综述可以帮助研究人员探索新的治疗策略,以提高 CDN 的治疗效果,CDN 作为天然无细胞疗法具有广阔的前景。
更新日期:2021-09-15
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