Asthma is a mysterious disease with heterogeneity in etiology, pathogenesis, and clinical phenotypes. Although ongoing studies have provided a better understanding of asthma, its natural history, progression, pathogenesis, diversified phenotypes, and even the exact epigenetic linkage between childhood asthma and adult-onset/old age asthma remain elusive in many aspects. Asthma heritability has been established through genetic studies, but genetics is not the only influencing factor in asthma. The increasing incidence and some unsolved queries suggest that there may be other elements related to asthma heredity. Epigenetic mechanisms link genetic and environmental factors with developmental trajectories in asthma. This review provides an overview of asthma epigenetics and its components, including several epigenetic studies on asthma, and discusses the epigenetic linkage between childhood asthma and adult-onset/old age asthma. Studies involving asthma epigenetics present valuable novel approaches to solve issues related to asthma. Asthma epigenetic research guides us towards gene therapy and personalized T cell therapy, directs the discovery of new therapeutic agents, predicts long-term outcomes in severe cases, and is also involved in the cellular transformation of childhood asthma to adult-onset/old age asthma.

中文翻译：

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表观遗传学在哮喘发病机制、治疗、预测和细胞转化中的作用

哮喘是一种在病因、发病机制和临床表型上具有异质性的神秘疾病。尽管正在进行的研究提供了对哮喘的更好理解，但其自然史、进展、发病机制、多样化的表型，甚至儿童哮喘与成人/老年哮喘之间的确切表观遗传联系在许多方面仍然难以捉摸。哮喘遗传性已通过基因研究确定，但遗传并不是哮喘的唯一影响因素。不断增加的发病率和一些未解决的问题表明可能存在与哮喘遗传相关的其他因素。表观遗传机制将遗传和环境因素与哮喘的发展轨迹联系起来。这篇综述概述了哮喘表观遗传学及其组成部分，包括几项关于哮喘的表观遗传学研究，并讨论了儿童哮喘与成人/老年哮喘之间的表观遗传联系。涉及哮喘表观遗传学的研究提出了解决哮喘相关问题的有价值的新方法。哮喘表观遗传学研究指导我们进行基因治疗和个性化 T 细胞治疗，指导新治疗剂的发现，预测严重病例的长期结果，并参与儿童哮喘向成人/老年哮喘的细胞转化.