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Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis
BioMed Research International ( IF 3.246 ) Pub Date : 2021-09-15 , DOI: 10.1155/2021/9853977
Ola Tarawneh 1 , Imad Hamadneh 2 , Rawan Huwaitat 1 , Ameen Rasheed Al-Assi 1 , Abdulla El Madani 1
Affiliation  

Periodontitis comprises a chronic inflammation that is initiated by microbiota biofilm. If left untreated, periodontitis may lead to permanent tooth loss. Herein, we propose to design and improve a localized form of therapy comprising a chlorhexidine-impregnated hydrogel. Hydrogel films were prepared by varying the ratio between cellulose (MCC) and carboxymethylcellulose sodium (CMC) using the crosslinker epichlorohydrin (ECH). The hydrogel was loaded with chlorhexidine. Increasing the CMC ratio led to a reduction in the number of pores, an increase in their size, lower glass transition temperature (), decreased Young’s modulus, and increased film stretching and affected the time of release. Bacterial and fungal zones of inhibition showed similar activity and were not affected by the CMC and MCC ratio. Hydrogels loaded with chlorhexidine prevented the growth of S. oralis and C. albicans microorganisms and may provide a promising local delivery system for treating periodontitis.

中文翻译:

用于治疗牙周炎的氯己定浸渍纤维素水凝胶膜的表征

牙周炎包括由微生物群生物膜引发的慢性炎症。如果不及时治疗,牙周炎可能会导致永久性牙齿脱落。在此,我们建议设计和改进包含洗必泰浸渍水凝胶的局部治疗形式。通过使用交联剂环氧氯丙烷 (ECH) 改变纤维素 (MCC) 和羧甲基纤维素钠 (CMC) 之间的比例来制备水凝胶薄膜。水凝胶装载有洗必泰。增加 CMC 比率会导致孔数量减少,孔尺寸增加,玻璃化转变温度降低 ( ),降低杨氏模量,增加薄膜拉伸,影响释放时间。细菌和真菌抑制区表现出相似的活性,并且不受 CMC 和 MCC 比率的影响。负载氯己定的水凝胶可防止口腔链球菌白色念珠菌微生物的生长,并可能为治疗牙周炎提供有前景的局部给药系统。
更新日期:2021-09-15
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