Evaluating outcome in osteoarthritis (OA) clinical research and practice requires reliable, valid and responsive patient-reported outcome measures (PROMs) and functional tests that reflect important problems experienced by people with OA. The goal of this work is to provide information to start to guide the reader in selecting measures for people with OA. In this narrative review, we begin by providing an overview of measurement properties that can help clinicians and researchers in making decisions about whether a measure might be appropriate for use in their research or clinical context. We then report evidence supporting the use of measures of pain (e.g., Pain Visual Analogue (VAS), Numeric Pain Rating Scale (NPRS), Intermittent and Constant Osteoarthritis Pain, PROMIS Pain Interference, and, for screening in research, the painDETECT and the Self-report Leeds Assessment of Neuropathic Symptoms and Signs) and fatigue (e.g., PROMIS-Fatigue) at a group level in clinical research. Several multi-dimensional joint-specific measures (e.g., Western Ontario McMaster Universities’ Osteoarthritis Outcomes Scale, Knee/Hip Injury and Osteoarthritis Outcome Score, Oxford Hip/Knee Scale) also have evidence for group-level use. Functional tests (e.g., timed walk tests, 30 Second Chair Stand, Timed Up and Go, etc.) have measurement properties supporting their use at the group level in clinical research and at the individual patient level as do the pain VAS and NPRS. Other generic and disease-specific PROMs have been used in or could be used in OA studies but their measurement properties require further evaluation in people with OA.

评估骨关节炎 (OA) 临床研究和实践的结果需要可靠、有效和反应迅速的患者报告结果测量 (PROM) 和功能测试，以反映 OA 患者所经历的重要问题。这项工作的目的是提供信息，以开始指导读者为 OA 患者选择措施。在这篇叙述性综述中，我们首先提供测量特性的概述，这些特性可以帮助临床医生和研究人员决定测量是否适合在他们的研究或临床环境中使用。然后，我们报告支持使用疼痛测量的证据（例如，疼痛视觉模拟 (VAS)、数字疼痛评定量表 (NPRS)、间歇性和持续性骨关节炎疼痛、PROMIS 疼痛干扰，以及用于研究筛查，临床研究中的组水平的疼痛检测和神经病症状和体征的自我报告利兹评估）和疲劳（例如，PROMIS-疲劳）。一些多维关节特异性测量（例如，西安大略麦克马斯特大学的骨关节炎结果量表、膝/髋关节损伤和骨关节炎结果评分、牛津髋/膝关节量表）也有证据可用于群体水平。功能测试（例如，定时步行测试、30 秒椅子站立、定时起立等）具有支持它们在临床研究中的群体水平和个体患者水平的测量特性，疼痛 VAS 和 NPRS 也是如此。其他通用和特定疾病的 PROM 已用于或可用于 OA 研究，但其测量特性需要在 OA 患者中进一步评估。