A diagnosis of neuropathy can typically be determined through clinical assessment and focused investigation. With technological advances, including significant progress in genomics, the role of nerve biopsy has receded over recent years. However, making a specific and, in some cases, tissue-based diagnosis is essential across a wide array of potentially treatable acquired peripheral neuropathies. When laboratory investigations do not suggest a definitive diagnosis, nerve biopsy remains the final step to ascertain the etiology of the disease. The present review highlights the utility of nerve biopsy in confirming a diagnosis, while further illustrating the importance of a tissue-based diagnosis in relation to treatment strategies, particularly when linked to long-term immunosuppressive therapies,

中文翻译：

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获得性神经病的神经活检

神经病变的诊断通常可以通过临床评估和重点调查来确定。随着技术的进步，包括基因组学的重大进步，神经活检的作用近年来已经减弱。然而，对各种可能可治疗的获得性周围神经病进行特定的并且在某些情况下基于组织的诊断是必不可少的。当实验室检查没有提出明确的诊断时，神经活检仍然是确定疾病病因的最后一步。本综述强调了神经活检在确诊中的作用，同时进一步说明了基于组织的诊断在治疗策略中的重要性，特别是与长期免疫抑制疗法相关时，