Background

COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak management. Our review aimed to analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic. Methods: A systematic review was performed from October 22 to 27, 2020, searching data published in PubMed and Google Scholar databases, using subject headings or keywords related to point of care and rapid test diagnostic for SARS-CoV-2 and COVID-19. Results: The first survey identified 403 articles, but only 23 met the defined criteria for the systematic analysis. The sensitivity and specificity parameters were assessed in 19 studies, and the data suggested that there was lower sensitivity in the period 1 to 7 days after the emergence of symptoms (∼38%) higher sensitivity at 8 to 14 days (∼90%), and the highest at 15 to 39 days (∼98%). Accuracy was reported in six studies, reporting values above 50%. Only three studies reported a possible cross-reaction. Conclusions: Our findings indicate that the rapid tests used in the first year of the pandemic were tested with a small number of samples and not adequately validated. And the studies that described them were conducted with little scientific rigor.

中文翻译：

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大流行第一年 COVID-19 的快速诊断：系统评价

背景

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 COVID-19 是一种全球健康威胁，仍然是现代医学面临的挑战。快速准确地诊断 COVID-19 对于适当的疾病和疫情管理至关重要。我们的审查旨在分析文献中发表的科学文章，这些文章涉及大流行第一年可用于 COVID-19 诊断的快速测试。方法：在 2020 年 10 月 22 日至 27 日期间进行了系统回顾，搜索了 PubMed 和 Google Scholar 数据库中发布的数据，使用与 SARS-CoV-2 和 COVID-19 的即时诊断和快速检测诊断相关的主题词或关键词。结果：第一次调查确定了 403 篇文章，但只有 23 篇符合系统分析的既定标准。在 19 项研究中评估了敏感性和特异性参数，数据表明，症状出现后 1 至 7 天的敏感性较低 (~38%)，8 至 14 天的敏感性较高 (~90%)，15 至 39 天的敏感性最高 (~98 %)。六项研究报告了准确性，报告值超过 50%。只有三项研究报告了可能的交叉反应。结论：我们的研究结果表明，在大流行的第一年使用的快速检测是用少量样本进行的，没有得到充分验证。描述它们的研究缺乏科学严谨性。只有三项研究报告了可能的交叉反应。结论：我们的研究结果表明，在大流行的第一年使用的快速检测是用少量样本进行的，没有得到充分验证。描述它们的研究缺乏科学严谨性。只有三项研究报告了可能的交叉反应。结论：我们的研究结果表明，在大流行的第一年使用的快速检测是用少量样本进行的，没有得到充分验证。描述它们的研究缺乏科学严谨性。