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Recent advances in synthesis and anti-tumor effect of organism-modified polyoxometalates inorganic organic hybrids
Inorganic Chemistry Communications ( IF 3.8 ) Pub Date : 2021-09-15 , DOI: 10.1016/j.inoche.2021.108904
Zhongzhong Cao 1, 2 , Wen Yang 1 , Xin Min 1 , Jianhua Liu 1, 2 , Xiaohua Cao 1, 2
Affiliation  

Inorganic polyoxometalates (POMs) have drawn extensive attentions in the fields of chemical catalysis, biological medicine, and energy-store material. Due to their remarkable performances on bioactivity especial in anti-tumor and anti-virus, POMs have been regarded as a novel and potential anti-tumor drug material. However, the purely inorganic POMs would bear obvious defects when they were applied in drug therapy, such as low solubility in organism and high-toxic on normal cell. Therefore, researchers in recent have paid great efforts to improve the solubility and anti-tumor activity of POMs by grafting organic functional groups onto inorganic parent frame. At present, as new and potential anti-tumor drug compounds, these inorganic organic hybrids generated by combining POMs and organic groups have become a hot spot and have been deeply studied around the world. Here in this review, we would like to summarize the important works that reported in the last five years, mainly about the synthetic routes, basic structures, and anti-tumor effects of POMs-organism hybrids.



中文翻译:

有机体修饰的多金属氧酸盐无机有机杂化物的合成及抗肿瘤作用研究进展

无机多金属氧酸盐(POMs)在化学催化、生物医药、储能材料等领域受到广泛关注。由于其在生物活性方面的显着表现,特别是在抗肿瘤和抗病毒方面,POMs 被认为是一种新的和潜在的抗肿瘤药物材料。然而,纯无机的POMs在应用于药物治疗时存在明显的缺陷,如在生物体中溶解度低,对正常细胞毒性大。因此,近年来研究人员通过将有机官能团接枝到无机母体框架上,努力提高POMs的溶解性和抗肿瘤活性。目前,作为新的和潜在的抗肿瘤药物化合物,这些由POMs与有机基团结合产生的无机有机杂化物已成为一个热点,并在世界范围内得到了深入研究。在这篇综述中,我们想总结一下过去五年来报道的重要工作,主要是关于 POM-生物杂种的合成路线、基本结构和抗肿瘤作用。

更新日期:2021-10-22
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