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Multifocal Urinary Tract Metastasis of Colorectal Carcinoma
Pathobiology ( IF 5 ) Pub Date : 2021-09-15 , DOI: 10.1159/000518967
Zsuzsanna Fejes 1 , István Előd Király 2 , Ádám Miklós Fehér 2 , Péter György Kovács 2 , Zoltán Gyuris 3 , Farkas Sükösd 4 , László Torday 5 , Levente Kuthi 4
Affiliation  

Introduction: Secondary urinary tract tumors are uncommon findings and mainly evolve by direct invasion from adjacent organs. Actual metastatic involvement often develops in the urinary bladder, while the upper urinary tract is infrequently affected. In addition, the lungs, breast, and prostate gland are the usual primary sites. Colorectal carcinoma (CRC) may spread to the ureter directly or seeds via vascular or lymphatic channels. It may pose struggles in the differential diagnosis because CRC shares standard pathologic features with the primary adenocarcinoma of the urinary tract. Case Presentation: We describe the case of an 81-year-old man who was referred to our hospital with a distal ureteral tumor that was treated by a ureteronephrectomy. The histopathological and genetic analysis established the diagnosis of metastatic CRC along with 3 metastases in the renal pelvis. Conclusion: This rare case highlights the limitations of conventional histological processing, including immunohistochemistry, and it underlines the role of molecular investigations in certain circumstances.
Pathobiology


中文翻译:

结直肠癌多灶性尿路转移

简介:继发性泌尿道肿瘤并不常见,主要通过邻近器官的直接侵袭发展而来。实际的转移性受累通常发生在膀胱中,而上尿路很少受到影响。此外,肺、乳房和前列腺是常见的主要部位。结直肠癌 (CRC) 可直接扩散至输尿管或通过血管或淋巴管扩散至种子。它可能在鉴别诊断中造成困难,因为 CRC 与原发性尿路腺癌具有共同的标准病理特征。案例介绍:我们描述了一名 81 岁男性的病例,他因输尿管远端肿瘤被转诊到我们医院,接受了输尿管肾切除术。组织病理学和遗传分析确定了转移性 CRC 的诊断以及肾盂中的 3 个转移。结论:这一罕见病例突出了包括免疫组织化学在内的常规组织学处理的局限性,并强调了分子研究在某些情况下的作用。
病理学
更新日期:2021-09-15
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