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Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins
Pharmaceutics ( IF 5.4 ) Pub Date : 2021-09-15 , DOI: 10.3390/pharmaceutics13091473
Ahmed Raslan 1 , Jesús Ciriza 2, 3, 4 , Ana María Ochoa de Retana 5 , María Luisa Sanjuán 6 , Muhammet S Toprak 7 , Patricia Galvez-Martin 8 , Laura Saenz-Del-Burgo 1, 2, 9 , Jose Luis Pedraz 1, 2, 9
Affiliation  

Modifying hydrogels in order to enhance their conductivity is an exciting field with applications in cardio and neuro-regenerative medicine. Therefore, we have designed hybrid alginate hydrogels containing uncoated and protein-coated reduced graphene oxide (rGO). We specifically studied the adsorption of three different proteins, BSA, elastin, and collagen, and the outcomes when these protein-coated rGO nanocomposites are embedded within the hydrogels. Our results demonstrate that BSA, elastin, and collagen are adsorbed onto the rGO surface, through a non-spontaneous phenomenon that fits Langmuir and pseudo-second-order adsorption models. Protein-coated rGOs are able to preclude further adsorption of erythropoietin, but not insulin. Collagen showed better adsorption capacity than BSA and elastin due to its hydrophobic nature, although requiring more energy. Moreover, collagen-coated rGO hybrid alginate hydrogels showed an enhancement in conductivity, showing that it could be a promising conductive scaffold for regenerative medicine.

中文翻译:

通过添加蛋白质调节含有还原氧化石墨烯的藻酸盐水凝胶的电导率

修改水凝胶以提高其导电性是一个令人兴奋的领域,可应用于心脏和神经再生医学。因此,我们设计了含有未涂层和蛋白质涂层还原氧化石墨烯 (rGO) 的混合藻酸盐水凝胶。我们专门研究了三种不同蛋白质、BSA、弹性蛋白和胶原蛋白的吸附,以及当这些蛋白质包覆的 rGO 纳米复合材料嵌入水凝胶中时的结果。我们的结果表明,BSA、弹性蛋白和胶原蛋白通过符合朗缪尔和伪二阶吸附模型的非自发现象吸附到 rGO 表面。蛋白质包被的 rGO 能够阻止促红细胞生成素的进一步吸附,但不能阻止胰岛素的吸附。由于其疏水性,胶原蛋白显示出比 BSA 和弹性蛋白更好的吸附能力,虽然需要更多的能量。此外,胶原包被的 rGO 混合海藻酸盐水凝胶显示出导电性的增强,表明它可能是一种有前途的再生医学导电支架。
更新日期:2021-09-15
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