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Hospital Admissions for Neurodegenerative Diseases during the First Wave of the COVID-19 Pandemic: A Nationwide Cross-sectional Study from Germany
Brain Sciences ( IF 3.3 ) Pub Date : 2021-09-15 , DOI: 10.3390/brainsci11091219
Raphael Scherbaum 1 , Eun-Hae Kwon 1 , Daniel Richter 1 , Dirk Bartig 2 , Ralf Gold 1, 3 , Christos Krogias 1 , Lars Tönges 1, 3
Affiliation  

(1) Background: The COVID-19 pandemic impacts healthcare utilization across all care settings and health conditions. The objective of this study was to determine changes in hospital admissions for neurodegenerative diseases (NDD) during the first COVID-19 wave in Germany; (2) Methods: This cross-sectional study used nationwide administrative claims data covering 1468 hospitals. The primary outcome was the year-to-year relative change in case numbers during a four-month study period (16 January–15 May 2020 vs. 2019) during the first pandemic wave. Secondary outcomes included year-to-year relative changes during a four-week peak phase (16 March–15 April) and changes between differential phases of the wave. The analyzed NDD comprised progressive supranuclear palsy (PSP), multiple system atrophy (MSA), Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and Huntington’s disease; (3) Results: Hospital admissions for any reason decreased by 16.7% in 2020 during the study period and by 36.6% during the peak phase, whereas admissions for NDD decreased by 27.6% and 65.0%, respectively. PSP cases decreased during the study period (−34.7%) and the peak phase (−68.1%) and stayed reduced in a late phase with falling COVID-19 numbers. MSA and ALS cases increased strongest after the peak, with ALS cases being comparatively weakly reduced during the study period (−17.3%) and peak phase (−51.7%); (4) Conclusions: Inpatient care utilization for NDD changed differentially during the first wave of the COVID-19 pandemic in Germany and showed a greater reduction than overall and general neurological admissions. Mitigating long-term health deterioration of this vulnerable subgroup is important to reduce morbidity and mortality in the future.

中文翻译:

在第一波 COVID-19 大流行期间因神经退行性疾病入院:来自德国的全国横断面研究

(1) 背景:COVID-19 大流行影响所有护理环境和健康状况的医疗保健利用。本研究的目的是确定德国第一波 COVID-19 浪潮期间神经退行性疾病 (NDD) 住院人数的变化;(2)方法:本横断面研究使用了全国1468家医院的行政理赔数据。主要结果是在第一波大流行期间四个月的研究期间(2020 年 1 月 16 日至 5 月 15 日与 2019 年)病例数的逐年相对变化。次要结果包括 4 周高峰期(3 月 16 日至 4 月 15 日)期间的逐年相对变化以及波浪不同阶段之间的变化。分析的 NDD 包括进行性核上性麻痹 (PSP)、多系统萎缩 (MSA)、帕金森病、肌萎缩侧索硬化(ALS)和亨廷顿病;(3)结果:研究期间2020年因各种原因住院下降16.7%,高峰期下降36.6%,而NDD入院率分别下降27.6%和65.0%。PSP 病例在研究期间 (-34.7%) 和高峰期 (-68.1%) 减少,并在后期随着 COVID-19 数量的下降而减少。MSA 和 ALS 病例在高峰后增长最为强劲,研究期间(-17.3%)和高峰期(-51.7%)ALS 病例减少相对较弱;(4) 结论:在德国第一波 COVID-19 大流行期间,NDD 的住院护理利用率发生了不同的变化,并且显示出比总体和一般神经病学入院率更大的下降。
更新日期:2021-09-15
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