Chronic bacteria infected wound repair poses a critical threat due to the deteriorating environment of the wound. Herein, with the reducibility of black phosphorus nanosheets (BPs), we designed two-dimensional antibacterial BP@AuNP nanocomposites by combining gold nanoparticles (AuNPs) with BPs, which possess photothermal properties and high singlet oxygen (¹O₂) production under 650 nm light, respectively. The BP@AuNP nanocomposites use a simple method to overcome the defects of BPs that require two kinds of light sources to perform photothermal and photodynamic therapies simultaneously and exhibited synergistic combination of multiple therapies for S. aureus and E. coli under a 650 nm laser. The antibacterial properties in vivo of the nanocomposites were also investigated and BPs@AuNPs possessed a fast wound closure rate. Thus, our BP@AuNP nanocomposites expand the application of BPs and demonstrate a versatile strategy for infected wound healing.

中文翻译：

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二维 BP@AuNP 纳米复合材料用于光热/光动力治疗介导的伤口消毒和单一光源下感染伤口愈合

由于伤口环境的恶化，慢性细菌感染的伤口修复构成了严重威胁。在此，利用黑磷纳米片 (BPs) 的可还原性，我们通过将金纳米粒子 (AuNPs) 与 BPs 结合设计了二维抗菌 BP@AuNP 纳米复合材料，该复合材料在 650 nm 下具有光热性能和高单线态氧 ( ¹ O ₂ ) 产量光，分别。BP@AuNP纳米复合材料采用简单的方法克服了BPs需要两种光源同时进行光热和光动力治疗的缺陷，在650 nm激光下对金黄色葡萄球菌和大肠杆菌表现出多种治疗的协同组合。抗菌性能还研究了纳米复合材料的体内BPs@AuNPs 具有快速的伤口闭合率。因此，我们的 BP@AuNP 纳米复合材料扩展了 BP 的应用，并展示了一种用于感染伤口愈合的通用策略。