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Early postnatal hypothyroidism reduces juvenile play behavior, but prenatal hypothyroidism compensates for these effects
Physiology & Behavior ( IF 2.9 ) Pub Date : 2021-09-15 , DOI: 10.1016/j.physbeh.2021.113594
Katharine V Northcutt 1 , Tanya S Leal-Medina 1 , Ye S Yoon 1
Affiliation  

Perinatal hypothyroidism causes long-lasting effects on behavior, including hyperactivity, cognitive delays/deficits, and a reduction in anxiety. Although there is some evidence that hypothyroidism during fetal development in humans has been associated with later autism spectrum disorder diagnosis or autism-like traits, the relationships between early thyroid hormones and social behaviors are largely unknown. Previously, we found that a moderate dose of the hypothyroid-inducing drug methimazole during embryonic and postnatal development dramatically increased juvenile play in male and female rats. The goal of the current study was to determine the extent to which thyroid hormones act in prenatal or postnatal development to organize later social behaviors. Subjects were exposed to methimazole in the drinking water during prenatal (embryonic day 12 to birth), postnatal (birth to postnatal day 23), or pre- and postnatal development; control animals received regular drinking water throughout the experiment. They were tested for play behavior as juveniles (P30–32). We found an interaction between pre- and postnatal methimazole administration such that postnatal hypothyroidism decreased some play behaviors, whereas sustained pre- and postnatal hypothyroidism restored play to control levels. The effects were similar in males and females. To our knowledge, this is the first report of an interaction between pre- and postnatal hypothyroidism on later behavior. The complexity of the timing of these effects may help explain why epidemiological studies have not consistently found a relationship between gestational hypothyroidism and later behavior.



中文翻译:

产后早期甲状腺功能减退症会减少青少年玩耍行为,但产前甲状腺功能减退症可以弥补这些影响

围产期甲状腺功能减退症会对行为产生长期影响,包括多动、认知延迟/缺陷和焦虑减少。尽管有一些证据表明人类胎儿发育期间的甲状腺功能减退症与后来的自闭症谱系障碍诊断或自闭症样特征有关,但早期甲状腺激素与社会行为之间的关系在很大程度上是未知的。以前,我们发现在胚胎和出生后发育期间中等剂量的甲状腺功能减退诱导药物甲巯咪唑可显着增加雄性和雌性大鼠的幼年活动。当前研究的目标是确定甲状腺激素在产前或产后发育中的作用程度,以组织以后的社会行为。受试者在产前(胚胎第 12 天到出生)、产后(出生到出生后第 23 天)或产前和产后发育期间暴露于饮用水中的甲巯咪唑;对照动物在整个实验过程中定期喝水。他们在青少年时期接受了游戏行为测试(P30-32)。我们发现产前和产后服用甲巯咪唑之间存在相互作用,产后甲状腺功能减退症会减少一些游戏行为,而持续的产前和产后甲状腺功能减退症将游戏恢复到控制水平。男性和女性的效果相似。据我们所知,这是关于产前和产后甲状腺功能减退症对以后行为的相互作用的第一份报告。

更新日期:2021-09-20
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