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Differential effects of ergometer-cycling and Whole-Body-Vibration training on serological BDNF and IGF-1 in the treatment of adolescent depression - is there an impact of BDNFp.Val66Met variants?
Physiology & Behavior ( IF 2.9 ) Pub Date : 2021-09-15 , DOI: 10.1016/j.physbeh.2021.113596
Heidrun Lioba Wunram 1 , Max Oberste 2 , Alischa Ziemendorff 3 , Stefanie Hamacher 2 , Tugba Kapanci 4 , Raoul Heller 5 , Serjosha Blick 6 , Wilhelm Bloch 7 , Theresia Christina Clajus 8 , Eckhard Schönau 9 , Stephan Bender 1 , Oliver Fricke 4
Affiliation  

Background

Pathogenesis and treatment of adolescent depression may be influenced by growth-factors, including brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1). We investigated, if treatment response to two different add-on exercise-therapies in juvenile depression, differ in the changes of BDNF and IGF-1 serology. A subgroup analysis for genetic variations in BDNF p.Val66Met-variants was added.

Methods

Included subjects in the study (N = 64), aged 13 to 17 years, were diagnosed with major depression, controls received inpatient treatment as usual (TAU). Intervention groups performed as add-on to TAU two different forms of exercise-therapy: endurance ergometer cycling (EC) and muscle strengthening whole body vibration (WBV). We expected both exercise-forms to increase BDNF and IGF-1 serology and by this pathway to improve depression scores significantly stronger than the control group.

Results

None of the experimental groups showed significant changes in BDNF between measurement time points. However, after 6 weeks exercise, BDNF of both intervention groups were significantly higher compared to TAU,. The IGF-1 increase after 6 weeks intervention was significant for EC only. No correlations of BDNF and IGF-1 to depression scores were found. Group analysis in BDNF p.Val66Met variants showed a trend for better response in depression scores to exercise-treatment for the Val66Val group.

Limitations

A small sample size, the non-randomized controls and the neglect of psychosocial factors have to be considered as limitations.

Conclusions

Endurance and muscle strengthening trainings seem to influence serological BDNF and IGF-1 differentially. However, the changes in growth factors did not correlate to the decreases in depression scores. BDNF p.Val66Val variant seems to be more receptive for exercise treatment. Identifying biomarkers (growth factors, genetic variants) in adolescent depression could help to develop tailored treatment strategies.



中文翻译:

测力计循环和全身振动训练对血清学 BDNF 和 IGF-1 治疗青少年抑郁症的不同影响 - BDNFp.Val66Met 变体是否有影响?

背景

青少年抑郁症的发病机制和治疗可能受到生长因子的影响,包括脑源性神经营养因子 (BDNF) 和胰岛素样生长因子 1 (IGF-1)。我们调查了,如果对青少年抑郁症中两种不同的附加运动疗法的治疗反应,BDNF 和 IGF-1 血清学的变化是否不同。添加了针对BDNF p.Val66Met 变体的遗传变异的亚组分析。

方法

研究中纳入的受试者 ( N  = 64),年龄在 13 至 17 岁之间,被诊断为重度抑郁症,对照组照常接受住院治疗 (TAU)。干预组作为 TAU 的附加进行了两种不同形式的运动疗法:耐力测力计循环 (EC) 和肌肉强化全身振动 (WBV)。我们预计这两种运动形式都会增加 BDNF 和 IGF-1 血清学,并通过这种途径改善抑郁症评分显着强于对照组。

结果

没有一个实验组在测量时间点之间显示出 BDNF 的显着变化。然而,在锻炼 6 周后,两个干预组的 BDNF 均显着高于 TAU。干预 6 周后 IGF-1 的增加仅对 EC 显着。没有发现 BDNF 和 IGF-1 与抑郁评分的相关性。BDNF p.Val66Met 变体的组分析显示,Val66Val 组的抑郁评分对运动治疗有更好的反应。

限制

小样本量、非随机对照和忽视社会心理因素必须被视为局限性。

结论

耐力和肌肉强化训练似乎对血清学 BDNF 和 IGF-1 有不同的影响。然而,生长因子的变化与抑郁评分的下降无关。BDNF p.Val66Val 变体似乎更容易接受运动治疗。识别青少年抑郁症的生物标志物(生长因子、遗传变异)有助于制定量身定制的治疗策略。

更新日期:2021-09-21
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