Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease,Journal of Cachexia, Sarcopenia and Muscle

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Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2021-09-15 , DOI: 10.1002/jcsm.12782
Preeti Lakshman Kumar ₁ , Ava C Wilson _{1,

2} , Alison Rocco _{1,

2} , Michael H Cho _{3,

4} , Emily Wan _{3,

5} , Brian D Hobbs _{3,

4} , George R Washko ₄ , Victor E Ortega ₆ , Stephanie A Christenson ₇ , Xingnan Li ₈ , J Michael Wells ₁ , Surya P Bhatt ₁ , Dawn L DeMeo _{3,

4} , Sharon M Lutz ₉ , Harry Rossiter ₁₀ , Richard Casaburi ₁₀ , Stephen I Rennard ₁₁ , David A Lomas ₁₂ , Wassim W Labaki ₁₃ , Ruth Tal-Singer ₁₄ , Russel P Bowler ₁₅ , Craig P Hersh _{3,

4} , Hemant K Tiwari ₁₆ , Mark Dransfield ₁ , Anna Thalacker-Mercer ₁₇ , Deborah A Meyers ₈ , Edwin K Silverman _{3,

4} , Merry-Lynn N McDonald _{1,

2,

18} ,

Affiliation

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Veterans Affairs Boston Health Care System, Jamaica Plain, Boston, MA, USA.
Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Division of Pulmonary, Critical Care, Allergy, & Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Department of Population Medicine, Harvard Medical School, Boston, MA, USA.
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Medicine, Nebraska Medical Center, Omaha, NE, USA.
UCL Respiratory, University College London, London, UK.
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
COPD Foundation, Miami, FL, USA.
Department of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, National Jewish Health, Denver, CO, USA.
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Cell Development and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with weight loss in COPD using a genome-wide association study approach.

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