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Bilateral Multiple Retinal Detachments Associated with Diffuse Large B-Cell Lymphoma: Masquerading as Vogt-Koyanagi-Harada Disease
Ocular Immunology and Inflammation ( IF 3.3 ) Pub Date : 2021-09-14 , DOI: 10.1080/09273948.2021.1952275
Ko Eun Lee 1 , Yoon Jeon Kim 1
Affiliation  

ABSTRACT

Purpose

We report a case of intraocular involvement in diffuse large B-cell lymphoma masquerading as Vogt-Koyanagi-Harada disease.

Methods

A 48-year-old woman presented with blurred vision in both eyes, fever, and hearing disturbance and underwent a complete ophthalmologic and systemic evaluation.

Results

Ophthalmologic examination showed bilateral exudative retinal detachment and signs of Vogt-Koyanagi-Harada disease. However, considering her generalized symptoms, systemic evaluation was performed before administering systemic steroid pulse therapy. In a systemic investigation, the patient was diagnosed with intraocular involvement in diffuse large B-cell lymphoma. After systemic chemotherapy, her bilateral visual acuity improved to 20/25 and the bilateral serous retinal detachment resolved.

Conclusion

In cases with prominent systemic symptoms, comprehensive systemic evaluation should be performed to rule out severe systemic conditions, such as malignancies.



中文翻译:

双侧多发性视网膜脱离与弥漫性大 B 细胞淋巴瘤相关:伪装成 Vogt-Koyanagi-Harada 病

摘要

目的

我们报告了一例伪装成 Vogt-Koyanagi-Harada 病的弥漫性大 B 细胞淋巴瘤眼内受累病例。

方法

一名 48 岁的女性因双眼视力模糊、发烧和听力障碍就诊,并接受了完整的眼科和全身评估。

结果

眼科检查显示双侧渗出性视网膜脱离和 Vogt-Koyanagi-Harada 病征。然而,考虑到她的全身症状,在给予全身性类固醇脉冲治疗之前进行了全身评估。在一项系统调查中,该患者被诊断为弥漫性大 B 细胞淋巴瘤眼内受累。全身化疗后,她的双侧视力提高到 20/25,双侧浆液性视网膜脱离得到解决。

结论

对于全身症状明显的病例,应进行全面的全身评估,排除恶性肿瘤等严重的全身性疾病。

更新日期:2021-09-14
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