Ocular Immunology and Inflammation ( IF 3.3 ) Pub Date : 2021-09-14 , DOI: 10.1080/09273948.2021.1952275 Ko Eun Lee 1 , Yoon Jeon Kim 1
ABSTRACT
Purpose
We report a case of intraocular involvement in diffuse large B-cell lymphoma masquerading as Vogt-Koyanagi-Harada disease.
Methods
A 48-year-old woman presented with blurred vision in both eyes, fever, and hearing disturbance and underwent a complete ophthalmologic and systemic evaluation.
Results
Ophthalmologic examination showed bilateral exudative retinal detachment and signs of Vogt-Koyanagi-Harada disease. However, considering her generalized symptoms, systemic evaluation was performed before administering systemic steroid pulse therapy. In a systemic investigation, the patient was diagnosed with intraocular involvement in diffuse large B-cell lymphoma. After systemic chemotherapy, her bilateral visual acuity improved to 20/25 and the bilateral serous retinal detachment resolved.
Conclusion
In cases with prominent systemic symptoms, comprehensive systemic evaluation should be performed to rule out severe systemic conditions, such as malignancies.
中文翻译:
双侧多发性视网膜脱离与弥漫性大 B 细胞淋巴瘤相关:伪装成 Vogt-Koyanagi-Harada 病
摘要
目的
我们报告了一例伪装成 Vogt-Koyanagi-Harada 病的弥漫性大 B 细胞淋巴瘤眼内受累病例。
方法
一名 48 岁的女性因双眼视力模糊、发烧和听力障碍就诊,并接受了完整的眼科和全身评估。
结果
眼科检查显示双侧渗出性视网膜脱离和 Vogt-Koyanagi-Harada 病征。然而,考虑到她的全身症状,在给予全身性类固醇脉冲治疗之前进行了全身评估。在一项系统调查中,该患者被诊断为弥漫性大 B 细胞淋巴瘤眼内受累。全身化疗后,她的双侧视力提高到 20/25,双侧浆液性视网膜脱离得到解决。
结论
对于全身症状明显的病例,应进行全面的全身评估,排除恶性肿瘤等严重的全身性疾病。