Abstract

Schiff base complexes of Cu(II), Ni(II), Co(II), VO(II) and Zn(II) ions have been synthesized by condensation of acetylaceto-4-iminoantipyrine and tyrosine. The structural characterization of compounds has been investigated using elemental analysis, molar conductance and magnetic susceptibility measurements, UV-Vis., FT-IR, ESI-mass, ¹H-NMR, ¹³C-NMR, ESR spectroscopy, cyclic voltammetry, XRD and SEM techniques. The observed analytical data indicate that the metal chelates have the general formula of [ML] type. Powder XRD pattern of Schiff base and its complexes authenticate their crystalline nature. From SEM morphology studies, the reduction grain size of Schiff base in metal chelates was observed which is due to the chelation of the Schiff base. From the IR, electronic absorption spectra and magnetic measurement data, square planar geometry was proposed for the metal complexes except for the [VOL] complex which exhibits square pyramidal geometry. The X-band ESR spectra of [CuL] and [VOL] complexes in DMSO solution were recorded at 77 & 300 K and their spin Hamiltonian parameter values support the proposed geometry. The interactions of the [CuL] complex with CT-DNA were investigated by UV-Vis and absorption titrations. DNA binding interaction studies reveal the hydrophobic interaction between CT-DNA and complexes. Furthermore, analgesic, anti-inflammatory, CNS and antimicrobial studies of the Schiff base and its transition metal complexes were examined and resolved metal complexes have enhanced pharmacological and biological activity when compared to free Schiff base. Molecular docking studies of the complex with DNA and (PDB ID: 6COX) protein were investigated.

摘要

Cu(II)、Ni(II)、Co(II)、VO(II) 和 Zn(II) 离子的席夫碱配合物已通过乙酰乙酰-4-亚氨基安替比林和酪氨酸的缩合合成。已经使用元素分析、摩尔电导和磁化率测量、UV-Vis.、FT-IR、ESI-质量、¹ H-NMR、^{13研究了化合物的结构表征}C-NMR、ESR光谱、循环伏安法、XRD和SEM技术。观察到的分析数据表明金属螯合物具有[ML]型的通式。席夫碱及其配合物的粉末 XRD 图证实了它们的结晶性质。从 SEM 形貌研究，观察到席夫碱在金属螯合物中的减小晶粒尺寸，这是由于席夫碱的螯合。从 IR、电子吸收光谱和磁测量数据来看，除了呈现方形锥体几何形状的 [VOL] 配合物外，提出了金属配合物的方形平面几何形状。DMSO 溶液中 [CuL] 和 [VOL] 配合物的 X 波段 ESR 光谱在 77 和 300 K 下记录，它们的自旋哈密顿参数值支持所提出的几何形状。[CuL] 复合物与 CT-DNA 的相互作用通过 UV-Vis 和吸收滴定进行了研究。DNA 结合相互作用研究揭示了 CT-DNA 和复合物之间的疏水相互作用。此外，对席夫碱及其过渡金属络合物的镇痛、抗炎、中枢神经系统和抗菌研究进行了检查，与游离席夫碱相比，分解的金属络合物具有增强的药理和生物活性。研究了复合物与 DNA 和 (PDB ID: 6COX) 蛋白的分子对接研究。对席夫碱及其过渡金属配合物的中枢神经系统和抗菌研究进行了检查，与游离席夫碱相比，分离的金属配合物具有增强的药理和生物活性。研究了复合物与 DNA 和 (PDB ID: 6COX) 蛋白的分子对接研究。对席夫碱及其过渡金属配合物的中枢神经系统和抗菌研究进行了检查，与游离席夫碱相比，分离的金属配合物具有增强的药理和生物活性。研究了复合物与 DNA 和 (PDB ID: 6COX) 蛋白的分子对接研究。