Chronic excessive fluoride exposure may lead to fluorosis, which causes health problems like a decrease in bone mechanical strength. It was speculated that chitosan may combine with fluorine to form in vivo organic fluorine, and may reduce the damage caused by fluorine. Hence, it is necessary to conduct a study to investigate the influence of chitosan on fluorosis mice. To investigate this problem, forty-four 4-week-old male Kunming mice were randomly divided into four groups, the control group, the fluoride group, the fluoride plus chitosan group, and the chitosan group. After 100 days of feeding, the femurs were collected to scan the Micro-CT image. The ultimate load of the femur in the fluoride group was significantly lower than control group. The trabecular separation was increased in the fluoride group compared with the fluoride plus chitosan group and the chitosan group. The level of trabecular thickness was increased in the fluoride plus chitosan group compared with the fluoride group. Our findings suggest that chitosan ingestion can improve the condition of cancellous bone and cortical bone affected by fluorine.

中文翻译：

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显微CT研究摄入壳聚糖缓解氟中毒小鼠骨损伤。

长期过量接触氟化物可能会导致氟中毒，从而导致骨骼机械强度下降等健康问题。据推测，壳聚糖可能与氟结合形成体内有机氟，并可能减轻氟造成的损害。因此，有必要开展壳聚糖对氟中毒小鼠的影响研究。为了研究这个问题，将44只4周龄的雄性昆明小鼠随机分为四组：对照组、氟化物组、氟化物加壳聚糖组和壳聚糖组。喂养100天后，收集股骨扫描Micro-CT图像。氟组股骨极限负荷显着低于对照组。与氟化物加壳聚糖组和壳聚糖组相比，氟化物组的小梁分离增加。与氟化物组相比，氟化物加壳聚糖组的小梁厚度水平增加。我们的研究结果表明，摄入壳聚糖可以改善受氟影响的松质骨和皮质骨的状况。