The Rhamnus alaternus plant is a rich source of excellent bioactive compounds including polyphenols and flavonoids. Yet, the improvement of the extraction yield of total polyphenol content (TPC) and total flavonoid content (TFC) from this plant has never been inspected in depth. Hence, using a 15-run Box-Behnken design, a dynamic maceration process was optimized for the extraction of TPC and TFC in order to investigate the antioxidant capacity of the various fractions by DPPH assay. Three factors (i.e., ratio of solvent-to-solid material plant, stirring speed and extraction time), were investigated and optimized for establishing a cost-effective process in order to produce extracts rich in phenolic components. With a desirability value of 0.970, the optimal extraction parameters of polyphenols and flavonoids were as follows: a ratio of solvent-to-solid of 10:1 mL/g, a stirring speed of 518 rpm, and 24 h of extraction. For such optimized conditions of dynamic maceration, the highest total polyphenols and total flavonoids contents were experimentally determined at 230.9 mg GAE/g and 121.1 mg QE/g of extract, respectively with an IC₅₀ value of 22.5 μg/mL, and were in agreement with the obtained model values.

的鼠李alaternus植物是丰富优秀的生物活性化合物包括多酚和类黄酮的来源。然而，该植物的总多酚含量（TPC）和总黄酮含量（TFC）提取率的提高从未被深入考察过。因此，使用 15 次运行的 Box-Behnken 设计，优化了动态浸渍过程以提取 TPC 和 TFC，以通过 DPPH 测定研究各种级分的抗氧化能力。三个因素（即溶剂与固体材料的比例、搅拌速度和提取时间）进行了研究和优化，以建立一种具有成本效益的工艺，以生产富含酚类成分的提取物。在合意值为0.970时，多酚和黄酮类化合物的最佳提取参数为：溶剂固比10:1 mL/g，搅拌速度518 rpm，提取时间24 h。对于这种优化的动态浸渍条件，通过实验测得最高的总多酚和总黄酮含量分别为 230.9 mg GAE/g 和 121.1 mg QE/g，IC ₅₀值为 22.5 μg/mL，结果一致与获得的模型值。